Cargando…
Assessment of COVID -19 associated coagulopathy and multiple hemostatic markers: a single center study in Egypt
BACKGROUND: Coagulopathy is still a serious pattern of coronavirus-19 disease. We aimed to evaluate COVID-19-associated coagulopathy and multiple hemostatic markers in Egyptian patients. In addition, to assess coagulation acute phase reactants and its effect on the outcome. METHODS: The study includ...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9510359/ https://www.ncbi.nlm.nih.gov/pubmed/36138306 http://dx.doi.org/10.1007/s15010-022-01917-5 |
_version_ | 1784797424533897216 |
---|---|
author | Abdelaal, Azza Abu-Elfatth, Ahmed Bakkar, Lamees M. El-Azeem, Hanan G. Abd Hetta, Helal F. Badawy, Eman R. |
author_facet | Abdelaal, Azza Abu-Elfatth, Ahmed Bakkar, Lamees M. El-Azeem, Hanan G. Abd Hetta, Helal F. Badawy, Eman R. |
author_sort | Abdelaal, Azza |
collection | PubMed |
description | BACKGROUND: Coagulopathy is still a serious pattern of coronavirus-19 disease. We aimed to evaluate COVID-19-associated coagulopathy and multiple hemostatic markers in Egyptian patients. In addition, to assess coagulation acute phase reactants and its effect on the outcome. METHODS: The study included 106 COVID-19 patients, and 51 controls. All patients were positive for COVID-19 infection by nasopharyngeal swab for detection of viral RNA by real-time PCR. In addition to baseline data and radiological findings, the coagulation profile was done with special attention to Fibrinogen, d-dimer, Factor VIII, von Willebrand factor (VWF), Protein C, Protein S, Antithrombin III (ATIII) and Lupus anticoagulant (LA)-1 and 2. RESULTS: The results showed significantly higher VWF, d-dimer, and LA1 (screening) and LA2 (confirmation) in patients than a control group. Significantly higher d-dimer FVIII, VWF and LA1-2 were detected in the severe group. ATIII had high diagnostic accuracy in severity prediction. We found a significantly higher international randomized ratio (INR) and VWF among patients with thrombotic events. For prediction of thrombosis; VWF at cutoff > 257.7 has 83.3% sensitivity and 83.3% specificity. CONCLUSION: Patients with COVID-19 infection are vulnerable to different forms of coagulopathy. This could be associated with poor outcomes. d-Dimer is a chief tool in diagnosis, severity evaluation but not thrombosis prediction. Early screening for this complication and its proper management would improve the outcome. |
format | Online Article Text |
id | pubmed-9510359 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-95103592022-09-26 Assessment of COVID -19 associated coagulopathy and multiple hemostatic markers: a single center study in Egypt Abdelaal, Azza Abu-Elfatth, Ahmed Bakkar, Lamees M. El-Azeem, Hanan G. Abd Hetta, Helal F. Badawy, Eman R. Infection Original Paper BACKGROUND: Coagulopathy is still a serious pattern of coronavirus-19 disease. We aimed to evaluate COVID-19-associated coagulopathy and multiple hemostatic markers in Egyptian patients. In addition, to assess coagulation acute phase reactants and its effect on the outcome. METHODS: The study included 106 COVID-19 patients, and 51 controls. All patients were positive for COVID-19 infection by nasopharyngeal swab for detection of viral RNA by real-time PCR. In addition to baseline data and radiological findings, the coagulation profile was done with special attention to Fibrinogen, d-dimer, Factor VIII, von Willebrand factor (VWF), Protein C, Protein S, Antithrombin III (ATIII) and Lupus anticoagulant (LA)-1 and 2. RESULTS: The results showed significantly higher VWF, d-dimer, and LA1 (screening) and LA2 (confirmation) in patients than a control group. Significantly higher d-dimer FVIII, VWF and LA1-2 were detected in the severe group. ATIII had high diagnostic accuracy in severity prediction. We found a significantly higher international randomized ratio (INR) and VWF among patients with thrombotic events. For prediction of thrombosis; VWF at cutoff > 257.7 has 83.3% sensitivity and 83.3% specificity. CONCLUSION: Patients with COVID-19 infection are vulnerable to different forms of coagulopathy. This could be associated with poor outcomes. d-Dimer is a chief tool in diagnosis, severity evaluation but not thrombosis prediction. Early screening for this complication and its proper management would improve the outcome. Springer Berlin Heidelberg 2022-09-22 2023 /pmc/articles/PMC9510359/ /pubmed/36138306 http://dx.doi.org/10.1007/s15010-022-01917-5 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Original Paper Abdelaal, Azza Abu-Elfatth, Ahmed Bakkar, Lamees M. El-Azeem, Hanan G. Abd Hetta, Helal F. Badawy, Eman R. Assessment of COVID -19 associated coagulopathy and multiple hemostatic markers: a single center study in Egypt |
title | Assessment of COVID -19 associated coagulopathy and multiple hemostatic markers: a single center study in Egypt |
title_full | Assessment of COVID -19 associated coagulopathy and multiple hemostatic markers: a single center study in Egypt |
title_fullStr | Assessment of COVID -19 associated coagulopathy and multiple hemostatic markers: a single center study in Egypt |
title_full_unstemmed | Assessment of COVID -19 associated coagulopathy and multiple hemostatic markers: a single center study in Egypt |
title_short | Assessment of COVID -19 associated coagulopathy and multiple hemostatic markers: a single center study in Egypt |
title_sort | assessment of covid -19 associated coagulopathy and multiple hemostatic markers: a single center study in egypt |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9510359/ https://www.ncbi.nlm.nih.gov/pubmed/36138306 http://dx.doi.org/10.1007/s15010-022-01917-5 |
work_keys_str_mv | AT abdelaalazza assessmentofcovid19associatedcoagulopathyandmultiplehemostaticmarkersasinglecenterstudyinegypt AT abuelfatthahmed assessmentofcovid19associatedcoagulopathyandmultiplehemostaticmarkersasinglecenterstudyinegypt AT bakkarlameesm assessmentofcovid19associatedcoagulopathyandmultiplehemostaticmarkersasinglecenterstudyinegypt AT elazeemhanangabd assessmentofcovid19associatedcoagulopathyandmultiplehemostaticmarkersasinglecenterstudyinegypt AT hettahelalf assessmentofcovid19associatedcoagulopathyandmultiplehemostaticmarkersasinglecenterstudyinegypt AT badawyemanr assessmentofcovid19associatedcoagulopathyandmultiplehemostaticmarkersasinglecenterstudyinegypt |