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Assessment of COVID -19 associated coagulopathy and multiple hemostatic markers: a single center study in Egypt

BACKGROUND: Coagulopathy is still a serious pattern of coronavirus-19 disease. We aimed to evaluate COVID-19-associated coagulopathy and multiple hemostatic markers in Egyptian patients. In addition, to assess coagulation acute phase reactants and its effect on the outcome. METHODS: The study includ...

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Autores principales: Abdelaal, Azza, Abu-Elfatth, Ahmed, Bakkar, Lamees M., El-Azeem, Hanan G. Abd, Hetta, Helal F., Badawy, Eman R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9510359/
https://www.ncbi.nlm.nih.gov/pubmed/36138306
http://dx.doi.org/10.1007/s15010-022-01917-5
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author Abdelaal, Azza
Abu-Elfatth, Ahmed
Bakkar, Lamees M.
El-Azeem, Hanan G. Abd
Hetta, Helal F.
Badawy, Eman R.
author_facet Abdelaal, Azza
Abu-Elfatth, Ahmed
Bakkar, Lamees M.
El-Azeem, Hanan G. Abd
Hetta, Helal F.
Badawy, Eman R.
author_sort Abdelaal, Azza
collection PubMed
description BACKGROUND: Coagulopathy is still a serious pattern of coronavirus-19 disease. We aimed to evaluate COVID-19-associated coagulopathy and multiple hemostatic markers in Egyptian patients. In addition, to assess coagulation acute phase reactants and its effect on the outcome. METHODS: The study included 106 COVID-19 patients, and 51 controls. All patients were positive for COVID-19 infection by nasopharyngeal swab for detection of viral RNA by real-time PCR. In addition to baseline data and radiological findings, the coagulation profile was done with special attention to Fibrinogen, d-dimer, Factor VIII, von Willebrand factor (VWF), Protein C, Protein S, Antithrombin III (ATIII) and Lupus anticoagulant (LA)-1 and 2. RESULTS: The results showed significantly higher VWF, d-dimer, and LA1 (screening) and LA2 (confirmation) in patients than a control group. Significantly higher d-dimer FVIII, VWF and LA1-2 were detected in the severe group. ATIII had high diagnostic accuracy in severity prediction. We found a significantly higher international randomized ratio (INR) and VWF among patients with thrombotic events. For prediction of thrombosis; VWF at cutoff > 257.7 has 83.3% sensitivity and 83.3% specificity. CONCLUSION: Patients with COVID-19 infection are vulnerable to different forms of coagulopathy. This could be associated with poor outcomes. d-Dimer is a chief tool in diagnosis, severity evaluation but not thrombosis prediction. Early screening for this complication and its proper management would improve the outcome.
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spelling pubmed-95103592022-09-26 Assessment of COVID -19 associated coagulopathy and multiple hemostatic markers: a single center study in Egypt Abdelaal, Azza Abu-Elfatth, Ahmed Bakkar, Lamees M. El-Azeem, Hanan G. Abd Hetta, Helal F. Badawy, Eman R. Infection Original Paper BACKGROUND: Coagulopathy is still a serious pattern of coronavirus-19 disease. We aimed to evaluate COVID-19-associated coagulopathy and multiple hemostatic markers in Egyptian patients. In addition, to assess coagulation acute phase reactants and its effect on the outcome. METHODS: The study included 106 COVID-19 patients, and 51 controls. All patients were positive for COVID-19 infection by nasopharyngeal swab for detection of viral RNA by real-time PCR. In addition to baseline data and radiological findings, the coagulation profile was done with special attention to Fibrinogen, d-dimer, Factor VIII, von Willebrand factor (VWF), Protein C, Protein S, Antithrombin III (ATIII) and Lupus anticoagulant (LA)-1 and 2. RESULTS: The results showed significantly higher VWF, d-dimer, and LA1 (screening) and LA2 (confirmation) in patients than a control group. Significantly higher d-dimer FVIII, VWF and LA1-2 were detected in the severe group. ATIII had high diagnostic accuracy in severity prediction. We found a significantly higher international randomized ratio (INR) and VWF among patients with thrombotic events. For prediction of thrombosis; VWF at cutoff > 257.7 has 83.3% sensitivity and 83.3% specificity. CONCLUSION: Patients with COVID-19 infection are vulnerable to different forms of coagulopathy. This could be associated with poor outcomes. d-Dimer is a chief tool in diagnosis, severity evaluation but not thrombosis prediction. Early screening for this complication and its proper management would improve the outcome. Springer Berlin Heidelberg 2022-09-22 2023 /pmc/articles/PMC9510359/ /pubmed/36138306 http://dx.doi.org/10.1007/s15010-022-01917-5 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Paper
Abdelaal, Azza
Abu-Elfatth, Ahmed
Bakkar, Lamees M.
El-Azeem, Hanan G. Abd
Hetta, Helal F.
Badawy, Eman R.
Assessment of COVID -19 associated coagulopathy and multiple hemostatic markers: a single center study in Egypt
title Assessment of COVID -19 associated coagulopathy and multiple hemostatic markers: a single center study in Egypt
title_full Assessment of COVID -19 associated coagulopathy and multiple hemostatic markers: a single center study in Egypt
title_fullStr Assessment of COVID -19 associated coagulopathy and multiple hemostatic markers: a single center study in Egypt
title_full_unstemmed Assessment of COVID -19 associated coagulopathy and multiple hemostatic markers: a single center study in Egypt
title_short Assessment of COVID -19 associated coagulopathy and multiple hemostatic markers: a single center study in Egypt
title_sort assessment of covid -19 associated coagulopathy and multiple hemostatic markers: a single center study in egypt
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9510359/
https://www.ncbi.nlm.nih.gov/pubmed/36138306
http://dx.doi.org/10.1007/s15010-022-01917-5
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