Single-cell transcriptome analysis reveals T-cell exhaustion in denosumab-treated giant cell tumor of bone

Denosumab (DMAB), a human monoclonal antibody against the receptor activator of the nuclear factor-kappa B ligand, is used for the treatment for unresectable giant cell tumor of bone (GCTB). However, little is known about the molecular and functional characteristics of GCTB-infiltrating lymphocytes...

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Detalles Bibliográficos
Autores principales: Yang, Meiling, Wang, Fen, Lu, Guohao, Cheng, Mingzhe, Zhao, Wei, Zou, Changye
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9510370/
https://www.ncbi.nlm.nih.gov/pubmed/36172351
http://dx.doi.org/10.3389/fimmu.2022.934078

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9510370/
https://www.ncbi.nlm.nih.gov/pubmed/36172351
http://dx.doi.org/10.3389/fimmu.2022.934078

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