Cargando…
Herpesvirus-Associated Encephalitis: an Update
PURPOSE OF REVIEW: Herpesviruses are a leading cause of encephalitis worldwide. The article reviews the eight human herpesviruses with a focus on recent advances as they pertain to encephalitis. RECENT FINDINGS: Notable recent updates include the development of multiplex polymerase chain reaction (P...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9510386/ https://www.ncbi.nlm.nih.gov/pubmed/36186545 http://dx.doi.org/10.1007/s40475-022-00255-8 |
_version_ | 1784797429942452224 |
---|---|
author | Matthews, Elizabeth Beckham, J. David Piquet, Amanda L. Tyler, Kenneth L. Chauhan, Lakshmi Pastula, Daniel M. |
author_facet | Matthews, Elizabeth Beckham, J. David Piquet, Amanda L. Tyler, Kenneth L. Chauhan, Lakshmi Pastula, Daniel M. |
author_sort | Matthews, Elizabeth |
collection | PubMed |
description | PURPOSE OF REVIEW: Herpesviruses are a leading cause of encephalitis worldwide. The article reviews the eight human herpesviruses with a focus on recent advances as they pertain to encephalitis. RECENT FINDINGS: Notable recent updates include the development of multiplex polymerase chain reaction (PCR)-based panels, which have improved access to PCR tests, especially in rural and resource-limited areas. Despite unchanged treatment recommendations, research is ongoing into novel therapies. There have been recent advances in vaccines, particularly for varicella zoster virus (VZV) which may impact neurologic complications. Finally, the recent discovery of an association between herpes encephalitis and post-infectious autoimmune encephalitis has had a critical impact on the fields of infectious and autoimmune neurology, though there remains much to learn. SUMMARY: Most herpesviruses are neurotropic and must be considered on the differential diagnosis for infectious encephalitis. This article describes recent advances in the diagnosis, treatment, complications, and management of these infections. |
format | Online Article Text |
id | pubmed-9510386 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-95103862022-09-26 Herpesvirus-Associated Encephalitis: an Update Matthews, Elizabeth Beckham, J. David Piquet, Amanda L. Tyler, Kenneth L. Chauhan, Lakshmi Pastula, Daniel M. Curr Trop Med Rep CNS Infections in Tropical Settings (C Franco-Paredes, Section Editor) PURPOSE OF REVIEW: Herpesviruses are a leading cause of encephalitis worldwide. The article reviews the eight human herpesviruses with a focus on recent advances as they pertain to encephalitis. RECENT FINDINGS: Notable recent updates include the development of multiplex polymerase chain reaction (PCR)-based panels, which have improved access to PCR tests, especially in rural and resource-limited areas. Despite unchanged treatment recommendations, research is ongoing into novel therapies. There have been recent advances in vaccines, particularly for varicella zoster virus (VZV) which may impact neurologic complications. Finally, the recent discovery of an association between herpes encephalitis and post-infectious autoimmune encephalitis has had a critical impact on the fields of infectious and autoimmune neurology, though there remains much to learn. SUMMARY: Most herpesviruses are neurotropic and must be considered on the differential diagnosis for infectious encephalitis. This article describes recent advances in the diagnosis, treatment, complications, and management of these infections. Springer International Publishing 2022-09-23 2022 /pmc/articles/PMC9510386/ /pubmed/36186545 http://dx.doi.org/10.1007/s40475-022-00255-8 Text en © The Author(s), under exclusive licence to Springer Nature Switzerland AG 2022, Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | CNS Infections in Tropical Settings (C Franco-Paredes, Section Editor) Matthews, Elizabeth Beckham, J. David Piquet, Amanda L. Tyler, Kenneth L. Chauhan, Lakshmi Pastula, Daniel M. Herpesvirus-Associated Encephalitis: an Update |
title | Herpesvirus-Associated Encephalitis: an Update |
title_full | Herpesvirus-Associated Encephalitis: an Update |
title_fullStr | Herpesvirus-Associated Encephalitis: an Update |
title_full_unstemmed | Herpesvirus-Associated Encephalitis: an Update |
title_short | Herpesvirus-Associated Encephalitis: an Update |
title_sort | herpesvirus-associated encephalitis: an update |
topic | CNS Infections in Tropical Settings (C Franco-Paredes, Section Editor) |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9510386/ https://www.ncbi.nlm.nih.gov/pubmed/36186545 http://dx.doi.org/10.1007/s40475-022-00255-8 |
work_keys_str_mv | AT matthewselizabeth herpesvirusassociatedencephalitisanupdate AT beckhamjdavid herpesvirusassociatedencephalitisanupdate AT piquetamandal herpesvirusassociatedencephalitisanupdate AT tylerkennethl herpesvirusassociatedencephalitisanupdate AT chauhanlakshmi herpesvirusassociatedencephalitisanupdate AT pastuladanielm herpesvirusassociatedencephalitisanupdate |