Nuclear-specific accumulation of telomerase reverse transcriptase (TERT) mRNA in TERT promoter mutated follicular thyroid tumours visualised by in situ hybridisation: a possible clinical screening tool?

AIMS: Upregulation of the telomerase reverse transcriptase (TERT) gene is a frequent finding in follicular thyroid carcinomas (FTCs) with metastatic features. The augmented expression is usually caused by TERT promoter mutations. As TERT protein immunohistochemistry might not correlate to TERT mRNA...

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Detalles Bibliográficos
Autores principales: Hellgren, L Samuel, Olsson, Ann, Kaufeldt, Ann, Paulsson, Johan O, Hysek, Martin, Stenman, Adam, Zedenius, Jan, Larsson, Catharina, Höög, Anders, Juhlin, C Christofer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9510436/
https://www.ncbi.nlm.nih.gov/pubmed/34011619
http://dx.doi.org/10.1136/jclinpath-2021-207631

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