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Facile synthesis of 6-organyl-4-(trifluoromethyl)pyridin-2(1H)-ones and their polyfluoroalkyl-containing analogs
The three-component cyclization of 3-polyfluoroalkyl-3-oxopropanoates and methyl ketones with ammonium acetate affords 6-organyl-4-(polyfluoroalkyl)pyridin-2(1H)-ones (organyl is alkyl, aryl, or hetaryl). The synthesized pyridones were evaluated for antifungal, antibacterial, and analgesic activity.
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer US
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9510450/ https://www.ncbi.nlm.nih.gov/pubmed/36185466 http://dx.doi.org/10.1007/s11172-022-3579-y |
| _version_ | 1784797443664117760 |
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| author | Kushch, S. O. Goryaeva, M. V. Burgart, Ya. V. Triandafilova, G. A. Malysheva, K. O. Krasnykh, O. P. Gerasimova, N. A. Evstigneeva, N. P. Saloutin, V. I. |
| author_facet | Kushch, S. O. Goryaeva, M. V. Burgart, Ya. V. Triandafilova, G. A. Malysheva, K. O. Krasnykh, O. P. Gerasimova, N. A. Evstigneeva, N. P. Saloutin, V. I. |
| author_sort | Kushch, S. O. |
| collection | PubMed |
| description | The three-component cyclization of 3-polyfluoroalkyl-3-oxopropanoates and methyl ketones with ammonium acetate affords 6-organyl-4-(polyfluoroalkyl)pyridin-2(1H)-ones (organyl is alkyl, aryl, or hetaryl). The synthesized pyridones were evaluated for antifungal, antibacterial, and analgesic activity. |
| format | Online Article Text |
| id | pubmed-9510450 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2022 |
| publisher | Springer US |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-95104502022-09-26 Facile synthesis of 6-organyl-4-(trifluoromethyl)pyridin-2(1H)-ones and their polyfluoroalkyl-containing analogs Kushch, S. O. Goryaeva, M. V. Burgart, Ya. V. Triandafilova, G. A. Malysheva, K. O. Krasnykh, O. P. Gerasimova, N. A. Evstigneeva, N. P. Saloutin, V. I. Russ Chem Bull Full Articles The three-component cyclization of 3-polyfluoroalkyl-3-oxopropanoates and methyl ketones with ammonium acetate affords 6-organyl-4-(polyfluoroalkyl)pyridin-2(1H)-ones (organyl is alkyl, aryl, or hetaryl). The synthesized pyridones were evaluated for antifungal, antibacterial, and analgesic activity. Springer US 2022-09-23 2022 /pmc/articles/PMC9510450/ /pubmed/36185466 http://dx.doi.org/10.1007/s11172-022-3579-y Text en © Springer Science+Business Media LLC 2022 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
| spellingShingle | Full Articles Kushch, S. O. Goryaeva, M. V. Burgart, Ya. V. Triandafilova, G. A. Malysheva, K. O. Krasnykh, O. P. Gerasimova, N. A. Evstigneeva, N. P. Saloutin, V. I. Facile synthesis of 6-organyl-4-(trifluoromethyl)pyridin-2(1H)-ones and their polyfluoroalkyl-containing analogs |
| title | Facile synthesis of 6-organyl-4-(trifluoromethyl)pyridin-2(1H)-ones and their polyfluoroalkyl-containing analogs |
| title_full | Facile synthesis of 6-organyl-4-(trifluoromethyl)pyridin-2(1H)-ones and their polyfluoroalkyl-containing analogs |
| title_fullStr | Facile synthesis of 6-organyl-4-(trifluoromethyl)pyridin-2(1H)-ones and their polyfluoroalkyl-containing analogs |
| title_full_unstemmed | Facile synthesis of 6-organyl-4-(trifluoromethyl)pyridin-2(1H)-ones and their polyfluoroalkyl-containing analogs |
| title_short | Facile synthesis of 6-organyl-4-(trifluoromethyl)pyridin-2(1H)-ones and their polyfluoroalkyl-containing analogs |
| title_sort | facile synthesis of 6-organyl-4-(trifluoromethyl)pyridin-2(1h)-ones and their polyfluoroalkyl-containing analogs |
| topic | Full Articles |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9510450/ https://www.ncbi.nlm.nih.gov/pubmed/36185466 http://dx.doi.org/10.1007/s11172-022-3579-y |
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