Facile synthesis of 6-organyl-4-(trifluoromethyl)pyridin-2(1H)-ones and their polyfluoroalkyl-containing analogs

The three-component cyclization of 3-polyfluoroalkyl-3-oxopropanoates and methyl ketones with ammonium acetate affords 6-organyl-4-(polyfluoroalkyl)pyridin-2(1H)-ones (organyl is alkyl, aryl, or hetaryl). The synthesized pyridones were evaluated for antifungal, antibacterial, and analgesic activity.

Detalles Bibliográficos
Autores principales: Kushch, S. O., Goryaeva, M. V., Burgart, Ya. V., Triandafilova, G. A., Malysheva, K. O., Krasnykh, O. P., Gerasimova, N. A., Evstigneeva, N. P., Saloutin, V. I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2022
Materias:
Full Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9510450/
https://www.ncbi.nlm.nih.gov/pubmed/36185466
http://dx.doi.org/10.1007/s11172-022-3579-y

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