Modulation of CD19 surface expression in B cell acute lymphoblastic leukemia

Immunotherapeutic targeting of the surface glycoprotein CD19 has markedly improved outcomes in patients with relapsed and refractory B cell progenitor acute lymphoblastic leukemia. Genome-wide CRISPR–Cas9 screening identifies modulators of CD19 mRNA processing that affect the abundance of the surfac...

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Detalles Bibliográficos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
Research Briefing
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9510525/
https://www.ncbi.nlm.nih.gov/pubmed/36151397
http://dx.doi.org/10.1038/s41590-022-01316-w
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collection PubMed
description Immunotherapeutic targeting of the surface glycoprotein CD19 has markedly improved outcomes in patients with relapsed and refractory B cell progenitor acute lymphoblastic leukemia. Genome-wide CRISPR–Cas9 screening identifies modulators of CD19 mRNA processing that affect the abundance of the surface protein in human B cell leukemia cells, with the potential to improve antigen-directed immunotherapy efficacy.
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spelling pubmed-95105252022-09-26 Modulation of CD19 surface expression in B cell acute lymphoblastic leukemia Nat Immunol Research Briefing Immunotherapeutic targeting of the surface glycoprotein CD19 has markedly improved outcomes in patients with relapsed and refractory B cell progenitor acute lymphoblastic leukemia. Genome-wide CRISPR–Cas9 screening identifies modulators of CD19 mRNA processing that affect the abundance of the surface protein in human B cell leukemia cells, with the potential to improve antigen-directed immunotherapy efficacy. Nature Publishing Group US 2022-09-23 2022 /pmc/articles/PMC9510525/ /pubmed/36151397 http://dx.doi.org/10.1038/s41590-022-01316-w Text en © The Author(s), under exclusive licence to Springer Nature America, Inc. 2022 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Research Briefing
Modulation of CD19 surface expression in B cell acute lymphoblastic leukemia
title Modulation of CD19 surface expression in B cell acute lymphoblastic leukemia
title_full Modulation of CD19 surface expression in B cell acute lymphoblastic leukemia
title_fullStr Modulation of CD19 surface expression in B cell acute lymphoblastic leukemia
title_full_unstemmed Modulation of CD19 surface expression in B cell acute lymphoblastic leukemia
title_short Modulation of CD19 surface expression in B cell acute lymphoblastic leukemia
title_sort modulation of cd19 surface expression in b cell acute lymphoblastic leukemia
topic Research Briefing
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9510525/
https://www.ncbi.nlm.nih.gov/pubmed/36151397
http://dx.doi.org/10.1038/s41590-022-01316-w

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