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A review of animal models for post-operative pericardial adhesions

Post-operative pericardial adhesions remain a serious complication after cardiac surgery that can lead to increased morbidity and mortality. Fibrous adhesions can destroy tissue planes leading to injury of surrounding vasculature, lengthening of operation time, and increased healthcare costs. While...

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Autores principales: Hill, Morgan A., Walkowiak, O. Agata, Head, William T., Kwon, Jennie H., Kavarana, Minoo N., Rajab, Taufiek Konrad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9510625/
https://www.ncbi.nlm.nih.gov/pubmed/36171819
http://dx.doi.org/10.3389/fsurg.2022.966410
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author Hill, Morgan A.
Walkowiak, O. Agata
Head, William T.
Kwon, Jennie H.
Kavarana, Minoo N.
Rajab, Taufiek Konrad
author_facet Hill, Morgan A.
Walkowiak, O. Agata
Head, William T.
Kwon, Jennie H.
Kavarana, Minoo N.
Rajab, Taufiek Konrad
author_sort Hill, Morgan A.
collection PubMed
description Post-operative pericardial adhesions remain a serious complication after cardiac surgery that can lead to increased morbidity and mortality. Fibrous adhesions can destroy tissue planes leading to injury of surrounding vasculature, lengthening of operation time, and increased healthcare costs. While animal models are necessary for studying the formation and prevention of post-operative pericardial adhesions, a standardized animal model for inducing post-operative pericardial adhesions has not yet been established. In order to address this barrier to progress, an analysis of the literature on animal models for post-operative pericardial adhesions was performed. The animal model, method used to induce adhesions, and the time to allow development of adhesions were analyzed. Our analysis found that introduction of autologous blood into the pericardial cavity in addition to physical abrasion of the epicardium caused more severe adhesion formation in comparison to abrasion alone or abrasion with desiccation (vs. abrasion alone p = 0.0002; vs. abrasion and desiccation p = 0.0184). The most common time frame allowed for adhesion formation was 2 weeks, with the shortest time being 10 days and the longest being 12 months. Finally, we found that the difference in adhesion severity in all animal species was similar, suggesting the major determinants for the choice of model are animal size, animal cost, and the availability of research tools in the particular model. This survey of the literature provides a rational guide for researchers to select the appropriate adhesion induction modality, animal model, and time allowed for the development of adhesions.
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spelling pubmed-95106252022-09-27 A review of animal models for post-operative pericardial adhesions Hill, Morgan A. Walkowiak, O. Agata Head, William T. Kwon, Jennie H. Kavarana, Minoo N. Rajab, Taufiek Konrad Front Surg Surgery Post-operative pericardial adhesions remain a serious complication after cardiac surgery that can lead to increased morbidity and mortality. Fibrous adhesions can destroy tissue planes leading to injury of surrounding vasculature, lengthening of operation time, and increased healthcare costs. While animal models are necessary for studying the formation and prevention of post-operative pericardial adhesions, a standardized animal model for inducing post-operative pericardial adhesions has not yet been established. In order to address this barrier to progress, an analysis of the literature on animal models for post-operative pericardial adhesions was performed. The animal model, method used to induce adhesions, and the time to allow development of adhesions were analyzed. Our analysis found that introduction of autologous blood into the pericardial cavity in addition to physical abrasion of the epicardium caused more severe adhesion formation in comparison to abrasion alone or abrasion with desiccation (vs. abrasion alone p = 0.0002; vs. abrasion and desiccation p = 0.0184). The most common time frame allowed for adhesion formation was 2 weeks, with the shortest time being 10 days and the longest being 12 months. Finally, we found that the difference in adhesion severity in all animal species was similar, suggesting the major determinants for the choice of model are animal size, animal cost, and the availability of research tools in the particular model. This survey of the literature provides a rational guide for researchers to select the appropriate adhesion induction modality, animal model, and time allowed for the development of adhesions. Frontiers Media S.A. 2022-09-12 /pmc/articles/PMC9510625/ /pubmed/36171819 http://dx.doi.org/10.3389/fsurg.2022.966410 Text en © 2022 Hill, Walkowiak, Head, Kwon, Kavarana and Rajab. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Surgery
Hill, Morgan A.
Walkowiak, O. Agata
Head, William T.
Kwon, Jennie H.
Kavarana, Minoo N.
Rajab, Taufiek Konrad
A review of animal models for post-operative pericardial adhesions
title A review of animal models for post-operative pericardial adhesions
title_full A review of animal models for post-operative pericardial adhesions
title_fullStr A review of animal models for post-operative pericardial adhesions
title_full_unstemmed A review of animal models for post-operative pericardial adhesions
title_short A review of animal models for post-operative pericardial adhesions
title_sort review of animal models for post-operative pericardial adhesions
topic Surgery
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9510625/
https://www.ncbi.nlm.nih.gov/pubmed/36171819
http://dx.doi.org/10.3389/fsurg.2022.966410
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