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The role of protein acetylation in carcinogenesis and targeted drug discovery
Protein acetylation is a reversible post-translational modification, and is involved in many biological processes in cells, such as transcriptional regulation, DNA damage repair, and energy metabolism, which is an important molecular event and is associated with a wide range of diseases such as canc...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9510633/ https://www.ncbi.nlm.nih.gov/pubmed/36171897 http://dx.doi.org/10.3389/fendo.2022.972312 |
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author | Yang, Jingru Song, Cong Zhan, Xianquan |
author_facet | Yang, Jingru Song, Cong Zhan, Xianquan |
author_sort | Yang, Jingru |
collection | PubMed |
description | Protein acetylation is a reversible post-translational modification, and is involved in many biological processes in cells, such as transcriptional regulation, DNA damage repair, and energy metabolism, which is an important molecular event and is associated with a wide range of diseases such as cancers. Protein acetylation is dynamically regulated by histone acetyltransferases (HATs) and histone deacetylases (HDACs) in homeostasis. The abnormal acetylation level might lead to the occurrence and deterioration of a cancer, and is closely related to various pathophysiological characteristics of a cancer, such as malignant phenotypes, and promotes cancer cells to adapt to tumor microenvironment. Therapeutic modalities targeting protein acetylation are a potential therapeutic strategy. This article discussed the roles of protein acetylation in tumor pathology and therapeutic drugs targeting protein acetylation, which offers the contributions of protein acetylation in clarification of carcinogenesis, and discovery of therapeutic drugs for cancers, and lays the foundation for precision medicine in oncology. |
format | Online Article Text |
id | pubmed-9510633 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-95106332022-09-27 The role of protein acetylation in carcinogenesis and targeted drug discovery Yang, Jingru Song, Cong Zhan, Xianquan Front Endocrinol (Lausanne) Endocrinology Protein acetylation is a reversible post-translational modification, and is involved in many biological processes in cells, such as transcriptional regulation, DNA damage repair, and energy metabolism, which is an important molecular event and is associated with a wide range of diseases such as cancers. Protein acetylation is dynamically regulated by histone acetyltransferases (HATs) and histone deacetylases (HDACs) in homeostasis. The abnormal acetylation level might lead to the occurrence and deterioration of a cancer, and is closely related to various pathophysiological characteristics of a cancer, such as malignant phenotypes, and promotes cancer cells to adapt to tumor microenvironment. Therapeutic modalities targeting protein acetylation are a potential therapeutic strategy. This article discussed the roles of protein acetylation in tumor pathology and therapeutic drugs targeting protein acetylation, which offers the contributions of protein acetylation in clarification of carcinogenesis, and discovery of therapeutic drugs for cancers, and lays the foundation for precision medicine in oncology. Frontiers Media S.A. 2022-09-12 /pmc/articles/PMC9510633/ /pubmed/36171897 http://dx.doi.org/10.3389/fendo.2022.972312 Text en Copyright © 2022 Yang, Song and Zhan https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Endocrinology Yang, Jingru Song, Cong Zhan, Xianquan The role of protein acetylation in carcinogenesis and targeted drug discovery |
title | The role of protein acetylation in carcinogenesis and targeted drug discovery |
title_full | The role of protein acetylation in carcinogenesis and targeted drug discovery |
title_fullStr | The role of protein acetylation in carcinogenesis and targeted drug discovery |
title_full_unstemmed | The role of protein acetylation in carcinogenesis and targeted drug discovery |
title_short | The role of protein acetylation in carcinogenesis and targeted drug discovery |
title_sort | role of protein acetylation in carcinogenesis and targeted drug discovery |
topic | Endocrinology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9510633/ https://www.ncbi.nlm.nih.gov/pubmed/36171897 http://dx.doi.org/10.3389/fendo.2022.972312 |
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