Cargando…

The role of protein acetylation in carcinogenesis and targeted drug discovery

Protein acetylation is a reversible post-translational modification, and is involved in many biological processes in cells, such as transcriptional regulation, DNA damage repair, and energy metabolism, which is an important molecular event and is associated with a wide range of diseases such as canc...

Descripción completa

Detalles Bibliográficos
Autores principales: Yang, Jingru, Song, Cong, Zhan, Xianquan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9510633/
https://www.ncbi.nlm.nih.gov/pubmed/36171897
http://dx.doi.org/10.3389/fendo.2022.972312
_version_ 1784797478605815808
author Yang, Jingru
Song, Cong
Zhan, Xianquan
author_facet Yang, Jingru
Song, Cong
Zhan, Xianquan
author_sort Yang, Jingru
collection PubMed
description Protein acetylation is a reversible post-translational modification, and is involved in many biological processes in cells, such as transcriptional regulation, DNA damage repair, and energy metabolism, which is an important molecular event and is associated with a wide range of diseases such as cancers. Protein acetylation is dynamically regulated by histone acetyltransferases (HATs) and histone deacetylases (HDACs) in homeostasis. The abnormal acetylation level might lead to the occurrence and deterioration of a cancer, and is closely related to various pathophysiological characteristics of a cancer, such as malignant phenotypes, and promotes cancer cells to adapt to tumor microenvironment. Therapeutic modalities targeting protein acetylation are a potential therapeutic strategy. This article discussed the roles of protein acetylation in tumor pathology and therapeutic drugs targeting protein acetylation, which offers the contributions of protein acetylation in clarification of carcinogenesis, and discovery of therapeutic drugs for cancers, and lays the foundation for precision medicine in oncology.
format Online
Article
Text
id pubmed-9510633
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-95106332022-09-27 The role of protein acetylation in carcinogenesis and targeted drug discovery Yang, Jingru Song, Cong Zhan, Xianquan Front Endocrinol (Lausanne) Endocrinology Protein acetylation is a reversible post-translational modification, and is involved in many biological processes in cells, such as transcriptional regulation, DNA damage repair, and energy metabolism, which is an important molecular event and is associated with a wide range of diseases such as cancers. Protein acetylation is dynamically regulated by histone acetyltransferases (HATs) and histone deacetylases (HDACs) in homeostasis. The abnormal acetylation level might lead to the occurrence and deterioration of a cancer, and is closely related to various pathophysiological characteristics of a cancer, such as malignant phenotypes, and promotes cancer cells to adapt to tumor microenvironment. Therapeutic modalities targeting protein acetylation are a potential therapeutic strategy. This article discussed the roles of protein acetylation in tumor pathology and therapeutic drugs targeting protein acetylation, which offers the contributions of protein acetylation in clarification of carcinogenesis, and discovery of therapeutic drugs for cancers, and lays the foundation for precision medicine in oncology. Frontiers Media S.A. 2022-09-12 /pmc/articles/PMC9510633/ /pubmed/36171897 http://dx.doi.org/10.3389/fendo.2022.972312 Text en Copyright © 2022 Yang, Song and Zhan https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Yang, Jingru
Song, Cong
Zhan, Xianquan
The role of protein acetylation in carcinogenesis and targeted drug discovery
title The role of protein acetylation in carcinogenesis and targeted drug discovery
title_full The role of protein acetylation in carcinogenesis and targeted drug discovery
title_fullStr The role of protein acetylation in carcinogenesis and targeted drug discovery
title_full_unstemmed The role of protein acetylation in carcinogenesis and targeted drug discovery
title_short The role of protein acetylation in carcinogenesis and targeted drug discovery
title_sort role of protein acetylation in carcinogenesis and targeted drug discovery
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9510633/
https://www.ncbi.nlm.nih.gov/pubmed/36171897
http://dx.doi.org/10.3389/fendo.2022.972312
work_keys_str_mv AT yangjingru theroleofproteinacetylationincarcinogenesisandtargeteddrugdiscovery
AT songcong theroleofproteinacetylationincarcinogenesisandtargeteddrugdiscovery
AT zhanxianquan theroleofproteinacetylationincarcinogenesisandtargeteddrugdiscovery
AT yangjingru roleofproteinacetylationincarcinogenesisandtargeteddrugdiscovery
AT songcong roleofproteinacetylationincarcinogenesisandtargeteddrugdiscovery
AT zhanxianquan roleofproteinacetylationincarcinogenesisandtargeteddrugdiscovery