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Dengue activates mTORC2 signaling to counteract apoptosis and maximize viral replication

The mechanistic target of rapamycin (mTOR) functions in two distinct complexes: mTORC1, and mTORC2. mTORC1 has been implicated in the pathogenesis of flaviviruses including dengue, where it contributes to the establishment of a pro-viral autophagic state. Activation of mTORC2 occurs upon infection w...

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Detalles Bibliográficos
Autores principales:	Carter, Christoph C., Mast, Fred D., Olivier, Jean Paul, Bourgeois, Natasha M., Kaushansky, Alexis, Aitchison, John D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Cellular and Infection Microbiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9510660/ https://www.ncbi.nlm.nih.gov/pubmed/36171757 http://dx.doi.org/10.3389/fcimb.2022.979996

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