Regulation and roles of FOXK2 in cancer

Forkhead box K2 (FOXK2) is a member of the forkhead box transcription factor family that contains an evolutionarily conserved winged-helix DNA-binding domain. Recently, an increasing number of studies have demonstrated that FOXK2 plays an important role in the transcriptional regulation of cancer. H...

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Detalles Bibliográficos
Autores principales: Kang, Yuanyuan, Zhang, Kexin, Sun, Lixue, Zhang, Ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9510715/
https://www.ncbi.nlm.nih.gov/pubmed/36172141
http://dx.doi.org/10.3389/fonc.2022.967625
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author Kang, Yuanyuan
Zhang, Kexin
Sun, Lixue
Zhang, Ying
author_facet Kang, Yuanyuan
Zhang, Kexin
Sun, Lixue
Zhang, Ying
author_sort Kang, Yuanyuan
collection PubMed
description Forkhead box K2 (FOXK2) is a member of the forkhead box transcription factor family that contains an evolutionarily conserved winged-helix DNA-binding domain. Recently, an increasing number of studies have demonstrated that FOXK2 plays an important role in the transcriptional regulation of cancer. Here, we provide an overview of the mechanisms underlying the regulation of FOXK2 expression and function and discuss the roles of FOXK2 in tumor pathogenesis. Additionally, we evaluated the prognostic value of FOXK2 expression in patients with various cancers. This review presents an overview of the different roles of FOXK2 in tumorigenesis and will help inform the design of experimental studies involving FOXK2. Ultimately, the information presented here will help enhance the therapeutic potential of FOXK2 as a cancer target.
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spelling pubmed-95107152022-09-27 Regulation and roles of FOXK2 in cancer Kang, Yuanyuan Zhang, Kexin Sun, Lixue Zhang, Ying Front Oncol Oncology Forkhead box K2 (FOXK2) is a member of the forkhead box transcription factor family that contains an evolutionarily conserved winged-helix DNA-binding domain. Recently, an increasing number of studies have demonstrated that FOXK2 plays an important role in the transcriptional regulation of cancer. Here, we provide an overview of the mechanisms underlying the regulation of FOXK2 expression and function and discuss the roles of FOXK2 in tumor pathogenesis. Additionally, we evaluated the prognostic value of FOXK2 expression in patients with various cancers. This review presents an overview of the different roles of FOXK2 in tumorigenesis and will help inform the design of experimental studies involving FOXK2. Ultimately, the information presented here will help enhance the therapeutic potential of FOXK2 as a cancer target. Frontiers Media S.A. 2022-09-12 /pmc/articles/PMC9510715/ /pubmed/36172141 http://dx.doi.org/10.3389/fonc.2022.967625 Text en Copyright © 2022 Kang, Zhang, Sun and Zhang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Kang, Yuanyuan
Zhang, Kexin
Sun, Lixue
Zhang, Ying
Regulation and roles of FOXK2 in cancer
title Regulation and roles of FOXK2 in cancer
title_full Regulation and roles of FOXK2 in cancer
title_fullStr Regulation and roles of FOXK2 in cancer
title_full_unstemmed Regulation and roles of FOXK2 in cancer
title_short Regulation and roles of FOXK2 in cancer
title_sort regulation and roles of foxk2 in cancer
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9510715/
https://www.ncbi.nlm.nih.gov/pubmed/36172141
http://dx.doi.org/10.3389/fonc.2022.967625
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