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Design, synthesis and biological evaluation of novel O-substituted tryptanthrin oxime derivatives as c-Jun N-terminal kinase inhibitors

The c-Jun N-terminal kinase (JNK) family includes three proteins (JNK1-3) that regulate many physiological processes, including inflammatory responses, morphogenesis, cell proliferation, differentiation, survival, and cell death. Therefore, JNK represents an attractive target for therapeutic interve...

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Detalles Bibliográficos
Autores principales:	Schepetkin, Igor A., Kovrizhina, Anastasia R., Stankevich, Ksenia S., Khlebnikov, Andrei I., Kirpotina, Liliya N., Quinn, Mark T., Cook, Matthew J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9510750/ https://www.ncbi.nlm.nih.gov/pubmed/36172181 http://dx.doi.org/10.3389/fphar.2022.958687

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