Manipulation of tissue factor-mediated basal PAR-2 signalling on macrophages determines sensitivity for IFNγ responsiveness and significantly modifies the phenotype of murine DTH

BACKGROUND: Tissue factor (TF) generates proteases that can signal through PAR-1 and PAR-2. We have previously demonstrated PAR-1 signalling primes innate myeloid cells to be exquisitely sensitive to interferon-gamma (IFNγ). In this work we explored how TF mediated PAR-2 signalling modulated respons...

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Detalles Bibliográficos
Autores principales: Wilkinson, Hannah, Leonard, Hugh, Robson, Michael G., Smith, Richard, Tam, ElLi, McVey, John H., Kirckhofer, Daniel, Chen, Daxin, Dorling, Anthony
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9510775/
https://www.ncbi.nlm.nih.gov/pubmed/36172348
http://dx.doi.org/10.3389/fimmu.2022.999871

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