Integrated single-cell RNA-seq analysis identifies immune heterogeneity associated with KRAS/TP53 mutation status and tumor-sideness in colorectal cancers

BACKGROUND: The main objective of this study was to analyze the effects of KRAS/TP53 mutation status and tumor sideness on the immune microenvironment of colorectal cancer using integrated scRNA-seq data. METHODS: A total of 78 scRNA-seq datasets, comprising 42 treatment-naive colorectal tumors, 13...

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Detalles Bibliográficos
Autores principales: Liu, Xiaoyu, Xu, Xu, Wu, Zhuozhuo, Shan, Qungang, Wang, Ziyin, Wu, Zhiyuan, Ding, Xiaoyi, Huang, Wei, Wang, Zhongmin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9510840/
https://www.ncbi.nlm.nih.gov/pubmed/36172359
http://dx.doi.org/10.3389/fimmu.2022.961350

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