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CSF circulation and dispersion yield rapid clearance from intracranial compartments
In this paper, we used a computational model to estimate the clearance of a tracer driven by the circulation of cerebrospinal fluid (CSF) produced in the choroid plexus (CP) located within the lateral ventricles. CSF was assumed to exit the subarachnoid space (SAS) via different outflow routes such...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9510842/ https://www.ncbi.nlm.nih.gov/pubmed/36172015 http://dx.doi.org/10.3389/fbioe.2022.932469 |
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author | Hornkjøl, Martin Valnes, Lars Magnus Ringstad, Geir Rognes, Marie E. Eide, Per-Kristian Mardal, Kent-André Vinje, Vegard |
author_facet | Hornkjøl, Martin Valnes, Lars Magnus Ringstad, Geir Rognes, Marie E. Eide, Per-Kristian Mardal, Kent-André Vinje, Vegard |
author_sort | Hornkjøl, Martin |
collection | PubMed |
description | In this paper, we used a computational model to estimate the clearance of a tracer driven by the circulation of cerebrospinal fluid (CSF) produced in the choroid plexus (CP) located within the lateral ventricles. CSF was assumed to exit the subarachnoid space (SAS) via different outflow routes such as the parasagittal dura, cribriform plate, and/or meningeal lymphatics. We also modelled a reverse case where fluid was produced within the spinal canal and absorbed in the choroid plexus in line with observations on certain iNPH patients. No directional interstitial fluid flow was assumed within the brain parenchyma. Tracers were injected into the foramen magnum. The models demonstrate that convection in the subarachnoid space yields rapid clearance from both the SAS and the brain interstitial fluid and can speed up intracranial clearance from years, as would be the case for purely diffusive transport, to days. |
format | Online Article Text |
id | pubmed-9510842 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-95108422022-09-27 CSF circulation and dispersion yield rapid clearance from intracranial compartments Hornkjøl, Martin Valnes, Lars Magnus Ringstad, Geir Rognes, Marie E. Eide, Per-Kristian Mardal, Kent-André Vinje, Vegard Front Bioeng Biotechnol Bioengineering and Biotechnology In this paper, we used a computational model to estimate the clearance of a tracer driven by the circulation of cerebrospinal fluid (CSF) produced in the choroid plexus (CP) located within the lateral ventricles. CSF was assumed to exit the subarachnoid space (SAS) via different outflow routes such as the parasagittal dura, cribriform plate, and/or meningeal lymphatics. We also modelled a reverse case where fluid was produced within the spinal canal and absorbed in the choroid plexus in line with observations on certain iNPH patients. No directional interstitial fluid flow was assumed within the brain parenchyma. Tracers were injected into the foramen magnum. The models demonstrate that convection in the subarachnoid space yields rapid clearance from both the SAS and the brain interstitial fluid and can speed up intracranial clearance from years, as would be the case for purely diffusive transport, to days. Frontiers Media S.A. 2022-09-12 /pmc/articles/PMC9510842/ /pubmed/36172015 http://dx.doi.org/10.3389/fbioe.2022.932469 Text en Copyright © 2022 Hornkjøl, Valnes, Ringstad, Rognes, Eide, Mardal and Vinje. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Bioengineering and Biotechnology Hornkjøl, Martin Valnes, Lars Magnus Ringstad, Geir Rognes, Marie E. Eide, Per-Kristian Mardal, Kent-André Vinje, Vegard CSF circulation and dispersion yield rapid clearance from intracranial compartments |
title | CSF circulation and dispersion yield rapid clearance from intracranial compartments |
title_full | CSF circulation and dispersion yield rapid clearance from intracranial compartments |
title_fullStr | CSF circulation and dispersion yield rapid clearance from intracranial compartments |
title_full_unstemmed | CSF circulation and dispersion yield rapid clearance from intracranial compartments |
title_short | CSF circulation and dispersion yield rapid clearance from intracranial compartments |
title_sort | csf circulation and dispersion yield rapid clearance from intracranial compartments |
topic | Bioengineering and Biotechnology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9510842/ https://www.ncbi.nlm.nih.gov/pubmed/36172015 http://dx.doi.org/10.3389/fbioe.2022.932469 |
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