A pilot study to examine association of BMI with functional class and 6 min walk distance in idiopathic and heritable PAH: Possible association with estrogen metabolism

The hypothesis that a relationship exists between body mass index (BMI), functional class, and 6 min walk distance (6MWD) in Group 1‐pulmonary arterial hypertension (PAH) was examined. Analysis of data from the UK National Cohort Study for heritable pulmonary arterial/idiopathic PAH suggests increas...

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Autores principales: MacLean, Margaret R., Pandya, Divya, Swietlik, Emilia M., Denver, Nina, Mair, Kirsty, Morrell, Nicholas W., Gräf, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9510900/
https://www.ncbi.nlm.nih.gov/pubmed/36186719
http://dx.doi.org/10.1002/pul2.12139
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author MacLean, Margaret R.
Pandya, Divya
Swietlik, Emilia M.
Denver, Nina
Mair, Kirsty
Morrell, Nicholas W.
Gräf, Stefan
author_facet MacLean, Margaret R.
Pandya, Divya
Swietlik, Emilia M.
Denver, Nina
Mair, Kirsty
Morrell, Nicholas W.
Gräf, Stefan
author_sort MacLean, Margaret R.
collection PubMed
description The hypothesis that a relationship exists between body mass index (BMI), functional class, and 6 min walk distance (6MWD) in Group 1‐pulmonary arterial hypertension (PAH) was examined. Analysis of data from the UK National Cohort Study for heritable pulmonary arterial/idiopathic PAH suggests increased BMI is a predictor of worse functional class and shorter 6MWD; increased body‐weight in mice and man may be associated with increased estrogen metabolism.
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spelling pubmed-95109002022-09-30 A pilot study to examine association of BMI with functional class and 6 min walk distance in idiopathic and heritable PAH: Possible association with estrogen metabolism MacLean, Margaret R. Pandya, Divya Swietlik, Emilia M. Denver, Nina Mair, Kirsty Morrell, Nicholas W. Gräf, Stefan Pulm Circ Research Letter The hypothesis that a relationship exists between body mass index (BMI), functional class, and 6 min walk distance (6MWD) in Group 1‐pulmonary arterial hypertension (PAH) was examined. Analysis of data from the UK National Cohort Study for heritable pulmonary arterial/idiopathic PAH suggests increased BMI is a predictor of worse functional class and shorter 6MWD; increased body‐weight in mice and man may be associated with increased estrogen metabolism. John Wiley and Sons Inc. 2022-07-01 /pmc/articles/PMC9510900/ /pubmed/36186719 http://dx.doi.org/10.1002/pul2.12139 Text en © 2022 The Authors. Pulmonary Circulation published by John Wiley & Sons Ltd on behalf of the Pulmonary Vascular Research Institute. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Letter
MacLean, Margaret R.
Pandya, Divya
Swietlik, Emilia M.
Denver, Nina
Mair, Kirsty
Morrell, Nicholas W.
Gräf, Stefan
A pilot study to examine association of BMI with functional class and 6 min walk distance in idiopathic and heritable PAH: Possible association with estrogen metabolism
title A pilot study to examine association of BMI with functional class and 6 min walk distance in idiopathic and heritable PAH: Possible association with estrogen metabolism
title_full A pilot study to examine association of BMI with functional class and 6 min walk distance in idiopathic and heritable PAH: Possible association with estrogen metabolism
title_fullStr A pilot study to examine association of BMI with functional class and 6 min walk distance in idiopathic and heritable PAH: Possible association with estrogen metabolism
title_full_unstemmed A pilot study to examine association of BMI with functional class and 6 min walk distance in idiopathic and heritable PAH: Possible association with estrogen metabolism
title_short A pilot study to examine association of BMI with functional class and 6 min walk distance in idiopathic and heritable PAH: Possible association with estrogen metabolism
title_sort pilot study to examine association of bmi with functional class and 6 min walk distance in idiopathic and heritable pah: possible association with estrogen metabolism
topic Research Letter
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9510900/
https://www.ncbi.nlm.nih.gov/pubmed/36186719
http://dx.doi.org/10.1002/pul2.12139
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