Common Postzygotic Mutational Signatures in Healthy Adult Tissues Related to Embryonic Hypoxia

Postzygotic mutations are acquired in normal tissues throughout an individual’s lifetime and hold clues for identifying mutagenic factors. Here, we investigated postzygotic mutation spectra of healthy individuals using optimized ultra-deep exome sequencing of the time-series samples from the same vo...

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Detalles Bibliográficos
Autores principales: Hong, Yaqiang, Zhang, Dake, Zhou, Xiangtian, Chen, Aili, Abliz, Amir, Bai, Jian, Wang, Liang, Hu, Qingtao, Gong, Kenan, Guan, Xiaonan, Liu, Mengfei, Zheng, Xinchang, Lai, Shujuan, Qu, Hongzhu, Zhao, Fuxin, Hao, Shuang, Wu, Zhen, Cai, Hong, Hu, Shaoyan, Ma, Yue, Zhang, Junting, Ke, Yang, Wang, Qian-Fei, Chen, Wei, Zeng, Changqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9510933/
https://www.ncbi.nlm.nih.gov/pubmed/34624550
http://dx.doi.org/10.1016/j.gpb.2021.09.005

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