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Evaluation of symmetric dimethylarginine in cats with acute kidney injury and chronic kidney disease

BACKGROUND: Serum symmetric dimethylarginine (SDMA) concentrations are considered a biomarker for renal dysfunction in dogs and humans with acute kidney injury (AKI). No studies have assessed SDMA in cats with AKI. HYPOTHESIS/OBJECTIVES: SDMA correctly identifies cats with azotemic AKI. ANIMALS: Fif...

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Autores principales: Loane, Samantha C., Thomson, James M., Williams, Timothy L., McCallum, Katie E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9511064/
https://www.ncbi.nlm.nih.gov/pubmed/35903963
http://dx.doi.org/10.1111/jvim.16497
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author Loane, Samantha C.
Thomson, James M.
Williams, Timothy L.
McCallum, Katie E.
author_facet Loane, Samantha C.
Thomson, James M.
Williams, Timothy L.
McCallum, Katie E.
author_sort Loane, Samantha C.
collection PubMed
description BACKGROUND: Serum symmetric dimethylarginine (SDMA) concentrations are considered a biomarker for renal dysfunction in dogs and humans with acute kidney injury (AKI). No studies have assessed SDMA in cats with AKI. HYPOTHESIS/OBJECTIVES: SDMA correctly identifies cats with azotemic AKI. ANIMALS: Fifteen control cats, 22 with novel AKI, 13 with acute on chronic‐AKI (AoC) and 19 with chronic kidney disease (CKD). METHODS: Retrospective study. Cats with azotemia (serum creatinine concentrations >1.7 mg/dL) were defined as having AKI or CKD based on history, clinical signs, clinicopathological findings and diagnostic imaging, and classified using the International Renal Interest Society (IRIS) grading/staging systems. Serum SDMA concentrations were compared between groups with nonparametric methods, and correlations assessed using Spearman's correlation coefficient. Data are presented as median [range]. RESULTS: SDMA concentrations were 11 (8‐21) μg/dL, 36 (9‐170)μg/dL, 33 (22‐75) μg/dL and 25 (12‐69) μg/dL in control, novel AKI, AoC and CKD cats. SDMA concentrations were significantly higher in cats with novel AKI (P < .001), AoC (P < .001) and CKD (P < .01) compared to controls. SDMA concentrations were significantly higher in cats with more advanced AKI (IRIS grade IV‐V) compared to less severe AKI (IRIS grade II). Serum creatinine and SDMA concentrations had a significant correlation in cats with novel AKI (r (s) = 0.826, n = 22; P < .001) and a significant correlation when all cats across all 4 groups were considered together (r ( s ) = 0.837, n = 69; P < .001). CONCLUSIONS AND CLINICAL IMPORTANCE: Serum SDMA concentrations are elevated in cats with established AKI (novel and AoC) and CKD, providing evidence for use of SDMA as a biomarker for AKI in cats.
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spelling pubmed-95110642022-09-30 Evaluation of symmetric dimethylarginine in cats with acute kidney injury and chronic kidney disease Loane, Samantha C. Thomson, James M. Williams, Timothy L. McCallum, Katie E. J Vet Intern Med SMALL ANIMAL BACKGROUND: Serum symmetric dimethylarginine (SDMA) concentrations are considered a biomarker for renal dysfunction in dogs and humans with acute kidney injury (AKI). No studies have assessed SDMA in cats with AKI. HYPOTHESIS/OBJECTIVES: SDMA correctly identifies cats with azotemic AKI. ANIMALS: Fifteen control cats, 22 with novel AKI, 13 with acute on chronic‐AKI (AoC) and 19 with chronic kidney disease (CKD). METHODS: Retrospective study. Cats with azotemia (serum creatinine concentrations >1.7 mg/dL) were defined as having AKI or CKD based on history, clinical signs, clinicopathological findings and diagnostic imaging, and classified using the International Renal Interest Society (IRIS) grading/staging systems. Serum SDMA concentrations were compared between groups with nonparametric methods, and correlations assessed using Spearman's correlation coefficient. Data are presented as median [range]. RESULTS: SDMA concentrations were 11 (8‐21) μg/dL, 36 (9‐170)μg/dL, 33 (22‐75) μg/dL and 25 (12‐69) μg/dL in control, novel AKI, AoC and CKD cats. SDMA concentrations were significantly higher in cats with novel AKI (P < .001), AoC (P < .001) and CKD (P < .01) compared to controls. SDMA concentrations were significantly higher in cats with more advanced AKI (IRIS grade IV‐V) compared to less severe AKI (IRIS grade II). Serum creatinine and SDMA concentrations had a significant correlation in cats with novel AKI (r (s) = 0.826, n = 22; P < .001) and a significant correlation when all cats across all 4 groups were considered together (r ( s ) = 0.837, n = 69; P < .001). CONCLUSIONS AND CLINICAL IMPORTANCE: Serum SDMA concentrations are elevated in cats with established AKI (novel and AoC) and CKD, providing evidence for use of SDMA as a biomarker for AKI in cats. John Wiley & Sons, Inc. 2022-07-29 2022 /pmc/articles/PMC9511064/ /pubmed/35903963 http://dx.doi.org/10.1111/jvim.16497 Text en © 2022 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals LLC on behalf of American College of Veterinary Internal Medicine. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle SMALL ANIMAL
Loane, Samantha C.
Thomson, James M.
Williams, Timothy L.
McCallum, Katie E.
Evaluation of symmetric dimethylarginine in cats with acute kidney injury and chronic kidney disease
title Evaluation of symmetric dimethylarginine in cats with acute kidney injury and chronic kidney disease
title_full Evaluation of symmetric dimethylarginine in cats with acute kidney injury and chronic kidney disease
title_fullStr Evaluation of symmetric dimethylarginine in cats with acute kidney injury and chronic kidney disease
title_full_unstemmed Evaluation of symmetric dimethylarginine in cats with acute kidney injury and chronic kidney disease
title_short Evaluation of symmetric dimethylarginine in cats with acute kidney injury and chronic kidney disease
title_sort evaluation of symmetric dimethylarginine in cats with acute kidney injury and chronic kidney disease
topic SMALL ANIMAL
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9511064/
https://www.ncbi.nlm.nih.gov/pubmed/35903963
http://dx.doi.org/10.1111/jvim.16497
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