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Associations of serum multivitamin levels with the risk of non-alcoholic fatty liver disease: A population-based cross-sectional study in U.S. adults

Vitamins were closely associated with non-alcoholic fatty liver disease (NAFLD) development, but no study had explored the association of serum multivitamin levels with NAFLD risk. We assessed the association between serum levels of both single-vitamin and multivitamins (VA, VB6, VB9, VB12, VC, VD,...

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Autores principales: Peng, Hongye, Wang, Miyuan, Pan, Liang, Cao, Zhengmin, Yao, Ziang, Chen, Qiuye, Li, Yanbo, Wang, Yuhua, Lv, Wenliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9511103/
https://www.ncbi.nlm.nih.gov/pubmed/36172527
http://dx.doi.org/10.3389/fnut.2022.962705
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author Peng, Hongye
Wang, Miyuan
Pan, Liang
Cao, Zhengmin
Yao, Ziang
Chen, Qiuye
Li, Yanbo
Wang, Yuhua
Lv, Wenliang
author_facet Peng, Hongye
Wang, Miyuan
Pan, Liang
Cao, Zhengmin
Yao, Ziang
Chen, Qiuye
Li, Yanbo
Wang, Yuhua
Lv, Wenliang
author_sort Peng, Hongye
collection PubMed
description Vitamins were closely associated with non-alcoholic fatty liver disease (NAFLD) development, but no study had explored the association of serum multivitamin levels with NAFLD risk. We assessed the association between serum levels of both single-vitamin and multivitamins (VA, VB6, VB9, VB12, VC, VD, and VE) and the risk of NAFLD, using the database of National Health and Nutrition Examination Survey (NHANES) (cycles 2003–2004 and 2005–2006). We employed multivariable logistic regression and weighted quantile sum (WQS) regression models to explore the association of serum multivitamin levels with NAFLD. Among all 2,294 participants, 969 participants with NAFLD were more likely to be male, older, less educated, or have hypertension/high cholesterol/diabetes. After adjustment of covariates, serum VC/VD/VB6/VB9 levels were negatively correlated with NAFLD risk, while serum VA/VE levels were positively correlated with NAFLD risk. In the WQS model, elevated serum VA/VE levels and lowered serum VC/VD/VB6 levels were linearly associated with increased NAFLD risk. There was a non-linear relationship between serum VB9/VB12 levels and NAFLD risk. There were evident associations between serum multivitamin levels and reduced NAFLD risk, which was mainly driven by VD/VB9/VC. In conclusion, our findings suggested that serum multivitamin levels were significantly associated with the risk of NAFLD.
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spelling pubmed-95111032022-09-27 Associations of serum multivitamin levels with the risk of non-alcoholic fatty liver disease: A population-based cross-sectional study in U.S. adults Peng, Hongye Wang, Miyuan Pan, Liang Cao, Zhengmin Yao, Ziang Chen, Qiuye Li, Yanbo Wang, Yuhua Lv, Wenliang Front Nutr Nutrition Vitamins were closely associated with non-alcoholic fatty liver disease (NAFLD) development, but no study had explored the association of serum multivitamin levels with NAFLD risk. We assessed the association between serum levels of both single-vitamin and multivitamins (VA, VB6, VB9, VB12, VC, VD, and VE) and the risk of NAFLD, using the database of National Health and Nutrition Examination Survey (NHANES) (cycles 2003–2004 and 2005–2006). We employed multivariable logistic regression and weighted quantile sum (WQS) regression models to explore the association of serum multivitamin levels with NAFLD. Among all 2,294 participants, 969 participants with NAFLD were more likely to be male, older, less educated, or have hypertension/high cholesterol/diabetes. After adjustment of covariates, serum VC/VD/VB6/VB9 levels were negatively correlated with NAFLD risk, while serum VA/VE levels were positively correlated with NAFLD risk. In the WQS model, elevated serum VA/VE levels and lowered serum VC/VD/VB6 levels were linearly associated with increased NAFLD risk. There was a non-linear relationship between serum VB9/VB12 levels and NAFLD risk. There were evident associations between serum multivitamin levels and reduced NAFLD risk, which was mainly driven by VD/VB9/VC. In conclusion, our findings suggested that serum multivitamin levels were significantly associated with the risk of NAFLD. Frontiers Media S.A. 2022-09-12 /pmc/articles/PMC9511103/ /pubmed/36172527 http://dx.doi.org/10.3389/fnut.2022.962705 Text en Copyright © 2022 Peng, Wang, Pan, Cao, Yao, Chen, Li, Wang and Lv. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Nutrition
Peng, Hongye
Wang, Miyuan
Pan, Liang
Cao, Zhengmin
Yao, Ziang
Chen, Qiuye
Li, Yanbo
Wang, Yuhua
Lv, Wenliang
Associations of serum multivitamin levels with the risk of non-alcoholic fatty liver disease: A population-based cross-sectional study in U.S. adults
title Associations of serum multivitamin levels with the risk of non-alcoholic fatty liver disease: A population-based cross-sectional study in U.S. adults
title_full Associations of serum multivitamin levels with the risk of non-alcoholic fatty liver disease: A population-based cross-sectional study in U.S. adults
title_fullStr Associations of serum multivitamin levels with the risk of non-alcoholic fatty liver disease: A population-based cross-sectional study in U.S. adults
title_full_unstemmed Associations of serum multivitamin levels with the risk of non-alcoholic fatty liver disease: A population-based cross-sectional study in U.S. adults
title_short Associations of serum multivitamin levels with the risk of non-alcoholic fatty liver disease: A population-based cross-sectional study in U.S. adults
title_sort associations of serum multivitamin levels with the risk of non-alcoholic fatty liver disease: a population-based cross-sectional study in u.s. adults
topic Nutrition
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9511103/
https://www.ncbi.nlm.nih.gov/pubmed/36172527
http://dx.doi.org/10.3389/fnut.2022.962705
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