Inhibitory targeting cGAS-STING-TBK1 axis: Emerging strategies for autoimmune diseases therapy

The cGAS-STING signaling plays an integral role in the host immune response, and the abnormal activation of cGAS-STING is highly related to various autoimmune diseases. Therefore, targeting the cGAS-STING-TBK1 axis has become a promising strategy in therapy of autoimmune diseases. Herein, we summari...

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Detalles Bibliográficos
Autores principales: Zhang, Min, Zou, Yan, Zhou, Xujun, Zhou, Jinming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9511411/
https://www.ncbi.nlm.nih.gov/pubmed/36172373
http://dx.doi.org/10.3389/fimmu.2022.954129
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author Zhang, Min
Zou, Yan
Zhou, Xujun
Zhou, Jinming
author_facet Zhang, Min
Zou, Yan
Zhou, Xujun
Zhou, Jinming
author_sort Zhang, Min
collection PubMed
description The cGAS-STING signaling plays an integral role in the host immune response, and the abnormal activation of cGAS-STING is highly related to various autoimmune diseases. Therefore, targeting the cGAS-STING-TBK1 axis has become a promising strategy in therapy of autoimmune diseases. Herein, we summarized the key pathways mediated by the cGAS-STING-TBK1 axis and various cGAS-STING-TBK1 related autoimmune diseases, as well as the recent development of cGAS, STING, or TBK1 selective inhibitors and their potential application in therapy of cGAS-STING-TBK1 related autoimmune diseases. Overall, the review highlights that inhibiting cGAS-STING-TBK1 signaling is an attractive strategy for autoimmune disease therapy.
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spelling pubmed-95114112022-09-27 Inhibitory targeting cGAS-STING-TBK1 axis: Emerging strategies for autoimmune diseases therapy Zhang, Min Zou, Yan Zhou, Xujun Zhou, Jinming Front Immunol Immunology The cGAS-STING signaling plays an integral role in the host immune response, and the abnormal activation of cGAS-STING is highly related to various autoimmune diseases. Therefore, targeting the cGAS-STING-TBK1 axis has become a promising strategy in therapy of autoimmune diseases. Herein, we summarized the key pathways mediated by the cGAS-STING-TBK1 axis and various cGAS-STING-TBK1 related autoimmune diseases, as well as the recent development of cGAS, STING, or TBK1 selective inhibitors and their potential application in therapy of cGAS-STING-TBK1 related autoimmune diseases. Overall, the review highlights that inhibiting cGAS-STING-TBK1 signaling is an attractive strategy for autoimmune disease therapy. Frontiers Media S.A. 2022-09-12 /pmc/articles/PMC9511411/ /pubmed/36172373 http://dx.doi.org/10.3389/fimmu.2022.954129 Text en Copyright © 2022 Zhang, Zou, Zhou and Zhou https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Zhang, Min
Zou, Yan
Zhou, Xujun
Zhou, Jinming
Inhibitory targeting cGAS-STING-TBK1 axis: Emerging strategies for autoimmune diseases therapy
title Inhibitory targeting cGAS-STING-TBK1 axis: Emerging strategies for autoimmune diseases therapy
title_full Inhibitory targeting cGAS-STING-TBK1 axis: Emerging strategies for autoimmune diseases therapy
title_fullStr Inhibitory targeting cGAS-STING-TBK1 axis: Emerging strategies for autoimmune diseases therapy
title_full_unstemmed Inhibitory targeting cGAS-STING-TBK1 axis: Emerging strategies for autoimmune diseases therapy
title_short Inhibitory targeting cGAS-STING-TBK1 axis: Emerging strategies for autoimmune diseases therapy
title_sort inhibitory targeting cgas-sting-tbk1 axis: emerging strategies for autoimmune diseases therapy
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9511411/
https://www.ncbi.nlm.nih.gov/pubmed/36172373
http://dx.doi.org/10.3389/fimmu.2022.954129
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