Antiviral activity of canine interferon lambda 3 expressed using a recombinant adenovirus against canine coronavirus, canine parvovirus, and canine distemper virus

Canine coronavirus (CCoV), canine parvovirus (CPV), and canine distemper virus (CDV) are highly contagious canine pathogens; dogs with these diseases are difficult to treat. In a previous study, we developed a recombinant adenovirus expressing canine interferon lambda 3 (Ad-caIFNλ3) in canine epithe...

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Autores principales: Kim, Dong-Hwi, Han, Sang-Hoon, Go, Hyeon-Jeong, Kim, Da-Yoon, Kim, Jae-Hyeong, Lee, Joong-Bok, Park, Seung-Yong, Song, Chang-Seon, Lee, Sang-Won, Choi, In-Soo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2022
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9511451/
https://www.ncbi.nlm.nih.gov/pubmed/36155869
http://dx.doi.org/10.1007/s11259-022-10000-1
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author Kim, Dong-Hwi
Han, Sang-Hoon
Go, Hyeon-Jeong
Kim, Da-Yoon
Kim, Jae-Hyeong
Lee, Joong-Bok
Park, Seung-Yong
Song, Chang-Seon
Lee, Sang-Won
Choi, In-Soo
author_facet Kim, Dong-Hwi
Han, Sang-Hoon
Go, Hyeon-Jeong
Kim, Da-Yoon
Kim, Jae-Hyeong
Lee, Joong-Bok
Park, Seung-Yong
Song, Chang-Seon
Lee, Sang-Won
Choi, In-Soo
author_sort Kim, Dong-Hwi
collection PubMed
description Canine coronavirus (CCoV), canine parvovirus (CPV), and canine distemper virus (CDV) are highly contagious canine pathogens; dogs with these diseases are difficult to treat. In a previous study, we developed a recombinant adenovirus expressing canine interferon lambda 3 (Ad-caIFNλ3) in canine epithelial cells. In this study, we aimed to investigate the antiviral activity of Ad-caIFNλ3 against CCoV, CPV, and CDV in two canine cell lines, A72 and MDCK. Ad-caIFNλ3 transduction suppressed replication of these viruses without cytotoxicity. Our results suggest that Ad-caIFNλ3 may be a therapeutic candidate for canine viral diseases. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s11259-022-10000-1.
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spelling pubmed-95114512022-09-26 Antiviral activity of canine interferon lambda 3 expressed using a recombinant adenovirus against canine coronavirus, canine parvovirus, and canine distemper virus Kim, Dong-Hwi Han, Sang-Hoon Go, Hyeon-Jeong Kim, Da-Yoon Kim, Jae-Hyeong Lee, Joong-Bok Park, Seung-Yong Song, Chang-Seon Lee, Sang-Won Choi, In-Soo Vet Res Commun Brief Report Canine coronavirus (CCoV), canine parvovirus (CPV), and canine distemper virus (CDV) are highly contagious canine pathogens; dogs with these diseases are difficult to treat. In a previous study, we developed a recombinant adenovirus expressing canine interferon lambda 3 (Ad-caIFNλ3) in canine epithelial cells. In this study, we aimed to investigate the antiviral activity of Ad-caIFNλ3 against CCoV, CPV, and CDV in two canine cell lines, A72 and MDCK. Ad-caIFNλ3 transduction suppressed replication of these viruses without cytotoxicity. Our results suggest that Ad-caIFNλ3 may be a therapeutic candidate for canine viral diseases. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s11259-022-10000-1. Springer Netherlands 2022-09-26 2022 /pmc/articles/PMC9511451/ /pubmed/36155869 http://dx.doi.org/10.1007/s11259-022-10000-1 Text en © The Author(s), under exclusive licence to Springer Nature B.V. 2022, Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Brief Report
Kim, Dong-Hwi
Han, Sang-Hoon
Go, Hyeon-Jeong
Kim, Da-Yoon
Kim, Jae-Hyeong
Lee, Joong-Bok
Park, Seung-Yong
Song, Chang-Seon
Lee, Sang-Won
Choi, In-Soo
Antiviral activity of canine interferon lambda 3 expressed using a recombinant adenovirus against canine coronavirus, canine parvovirus, and canine distemper virus
title Antiviral activity of canine interferon lambda 3 expressed using a recombinant adenovirus against canine coronavirus, canine parvovirus, and canine distemper virus
title_full Antiviral activity of canine interferon lambda 3 expressed using a recombinant adenovirus against canine coronavirus, canine parvovirus, and canine distemper virus
title_fullStr Antiviral activity of canine interferon lambda 3 expressed using a recombinant adenovirus against canine coronavirus, canine parvovirus, and canine distemper virus
title_full_unstemmed Antiviral activity of canine interferon lambda 3 expressed using a recombinant adenovirus against canine coronavirus, canine parvovirus, and canine distemper virus
title_short Antiviral activity of canine interferon lambda 3 expressed using a recombinant adenovirus against canine coronavirus, canine parvovirus, and canine distemper virus
title_sort antiviral activity of canine interferon lambda 3 expressed using a recombinant adenovirus against canine coronavirus, canine parvovirus, and canine distemper virus
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9511451/
https://www.ncbi.nlm.nih.gov/pubmed/36155869
http://dx.doi.org/10.1007/s11259-022-10000-1
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