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Discovery of β-Arrestin-Biased 25CN-NBOH-Derived 5-HT(2A) Receptor Agonists

[Image: see text] The serotonin 2A receptor (5-HT(2A)R) is the mediator of the psychedelic effects of serotonergic psychedelics, which have shown promising results in clinical studies for several neuropsychiatric indications. The 5-HT(2A)R is able to signal through the Gα(q) and β-arrestin effector...

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Detalles Bibliográficos
Autores principales:	Poulie, Christian B. M., Pottie, Eline, Simon, Icaro A., Harpsøe, Kasper, D’Andrea, Laura, Komarov, Igor V., Gloriam, David E., Jensen, Anders A., Stove, Christophe P., Kristensen, Jesper L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2022
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9511481/ https://www.ncbi.nlm.nih.gov/pubmed/36099411 http://dx.doi.org/10.1021/acs.jmedchem.2c00702

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