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Lamellipodia-like actin networks in cells lacking WAVE regulatory complex

Cell migration frequently involves the formation of lamellipodia induced by Rac GTPases activating WAVE regulatory complex (WRC) to drive Arp2/3 complex-dependent actin assembly. Previous genome editing studies in B16-F1 melanoma cells solidified the view of an essential, linear pathway employing th...

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Detalles Bibliográficos
Autores principales: Kage, Frieda, Döring, Hermann, Mietkowska, Magdalena, Schaks, Matthias, Grüner, Franziska, Stahnke, Stephanie, Steffen, Anika, Müsken, Mathias, Stradal, Theresia E. B., Rottner, Klemens
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9511706/
https://www.ncbi.nlm.nih.gov/pubmed/35971979
http://dx.doi.org/10.1242/jcs.260364