Cargando…
Lamellipodia-like actin networks in cells lacking WAVE regulatory complex
Cell migration frequently involves the formation of lamellipodia induced by Rac GTPases activating WAVE regulatory complex (WRC) to drive Arp2/3 complex-dependent actin assembly. Previous genome editing studies in B16-F1 melanoma cells solidified the view of an essential, linear pathway employing th...
Autores principales: | Kage, Frieda, Döring, Hermann, Mietkowska, Magdalena, Schaks, Matthias, Grüner, Franziska, Stahnke, Stephanie, Steffen, Anika, Müsken, Mathias, Stradal, Theresia E. B., Rottner, Klemens |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Company of Biologists Ltd
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9511706/ https://www.ncbi.nlm.nih.gov/pubmed/35971979 http://dx.doi.org/10.1242/jcs.260364 |
Ejemplares similares
-
RhoG and Cdc42 can contribute to Rac-dependent lamellipodia formation through WAVE regulatory complex-binding
por: Schaks, Matthias, et al.
Publicado: (2019) -
Efficiency of lamellipodia protrusion is determined by the extent of cytosolic actin assembly
por: Dimchev, Georgi, et al.
Publicado: (2017) -
Distinct Interaction Sites of Rac GTPase with WAVE Regulatory Complex Have Non-redundant Functions in Vivo
por: Schaks, Matthias, et al.
Publicado: (2018) -
The structure of FMNL2–Cdc42 yields insights into the mechanism of lamellipodia and filopodia formation
por: Kühn, Sonja, et al.
Publicado: (2015) -
Arp2/3 complex interactions and actin network turnover in lamellipodia
por: Lai, Frank PL, et al.
Publicado: (2008)