Gasdermin B over-expression modulates HER2-targeted therapy resistance by inducing protective autophagy through Rab7 activation

BACKGROUND: Gasdermin B (GSDMB) over-expression promotes poor prognosis and aggressive behavior in HER2 breast cancer by increasing resistance to therapy. Decoding the molecular mechanism of GSDMB-mediated drug resistance is crucial to identify novel effective targeted treatments for HER2/GSDMB aggr...

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Detalles Bibliográficos
Autores principales: Gámez-Chiachio, Manuel, Molina-Crespo, Ángela, Ramos-Nebot, Carmen, Martinez-Val, Jeannette, Martinez, Lidia, Gassner, Katja, Llobet, Francisco J., Soriano, Mario, Hernandez, Alberto, Cordani, Marco, Bernadó-Morales, Cristina, Diaz, Eva, Rojo-Sebastian, Alejandro, Triviño, Juan Carlos, Sanchez, Laura, Rodríguez-Barrueco, Ruth, Arribas, Joaquín, Llobet-Navás, David, Sarrió, David, Moreno-Bueno, Gema
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9511784/
https://www.ncbi.nlm.nih.gov/pubmed/36163066
http://dx.doi.org/10.1186/s13046-022-02497-w

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