Insight into the molecular mechanisms of gastric cancer stem cell in drug resistance of gastric cancer

Gastric cancer (GC) is one of the most common causes of cancer-related death worldwide, and gastric cancer stem cells (GCSCs) are considered as the major factor for resistance to conventional radio- and chemotherapy. Accumulating evidence in recent years implies that GCSCs regulate the drug resistan...

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Autores principales: Xiong, Jixian, Zhang, Tiantian, Lan, Penglin, Zhang, Shuhong, Fu, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: OAE Publishing Inc. 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9511795/
https://www.ncbi.nlm.nih.gov/pubmed/36176765
http://dx.doi.org/10.20517/cdr.2022.11
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author Xiong, Jixian
Zhang, Tiantian
Lan, Penglin
Zhang, Shuhong
Fu, Li
author_facet Xiong, Jixian
Zhang, Tiantian
Lan, Penglin
Zhang, Shuhong
Fu, Li
author_sort Xiong, Jixian
collection PubMed
description Gastric cancer (GC) is one of the most common causes of cancer-related death worldwide, and gastric cancer stem cells (GCSCs) are considered as the major factor for resistance to conventional radio- and chemotherapy. Accumulating evidence in recent years implies that GCSCs regulate the drug resistance in GC through multiple mechanisms, including dormancy, drug trafficking, drug metabolism and targeting, apoptosis, DNA damage, epithelial-mesenchymal transition, and tumor microenvironment. In this review, we summarize current advancements regarding the relationship between GCSCs and drug resistance and evaluate the molecular bases of GCSCs in drug resistance.
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spelling pubmed-95117952022-09-28 Insight into the molecular mechanisms of gastric cancer stem cell in drug resistance of gastric cancer Xiong, Jixian Zhang, Tiantian Lan, Penglin Zhang, Shuhong Fu, Li Cancer Drug Resist Review Gastric cancer (GC) is one of the most common causes of cancer-related death worldwide, and gastric cancer stem cells (GCSCs) are considered as the major factor for resistance to conventional radio- and chemotherapy. Accumulating evidence in recent years implies that GCSCs regulate the drug resistance in GC through multiple mechanisms, including dormancy, drug trafficking, drug metabolism and targeting, apoptosis, DNA damage, epithelial-mesenchymal transition, and tumor microenvironment. In this review, we summarize current advancements regarding the relationship between GCSCs and drug resistance and evaluate the molecular bases of GCSCs in drug resistance. OAE Publishing Inc. 2022-07-01 /pmc/articles/PMC9511795/ /pubmed/36176765 http://dx.doi.org/10.20517/cdr.2022.11 Text en © The Author(s) 2022. https://creativecommons.org/licenses/by/4.0/© The Author(s) 2022. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, sharing, adaptation, distribution and reproduction in any medium or format, for any purpose, even commercially, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Review
Xiong, Jixian
Zhang, Tiantian
Lan, Penglin
Zhang, Shuhong
Fu, Li
Insight into the molecular mechanisms of gastric cancer stem cell in drug resistance of gastric cancer
title Insight into the molecular mechanisms of gastric cancer stem cell in drug resistance of gastric cancer
title_full Insight into the molecular mechanisms of gastric cancer stem cell in drug resistance of gastric cancer
title_fullStr Insight into the molecular mechanisms of gastric cancer stem cell in drug resistance of gastric cancer
title_full_unstemmed Insight into the molecular mechanisms of gastric cancer stem cell in drug resistance of gastric cancer
title_short Insight into the molecular mechanisms of gastric cancer stem cell in drug resistance of gastric cancer
title_sort insight into the molecular mechanisms of gastric cancer stem cell in drug resistance of gastric cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9511795/
https://www.ncbi.nlm.nih.gov/pubmed/36176765
http://dx.doi.org/10.20517/cdr.2022.11
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AT zhangshuhong insightintothemolecularmechanismsofgastriccancerstemcellindrugresistanceofgastriccancer
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