Relationships among microbiota, gastric cancer, and immunotherapy

Currently, conventional neoadjuvant therapy or postoperative adjuvant therapy, such as chemotherapy and radiation therapy, can only bring limited survival benefits to gastric cancer (GC). Median survival after palliative chemotherapy is also low, at about 8–10 months. Immunotargeting is a new option...

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Autores principales: Li, Yuzhen, Huang, Xiaona, Tong, Desheng, Jiang, Chenyu, Zhu, Xiaodan, Wei, Zhipeng, Gong, Tingjie, Jin, Chunhui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9511979/
https://www.ncbi.nlm.nih.gov/pubmed/36171746
http://dx.doi.org/10.3389/fmicb.2022.987763
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author Li, Yuzhen
Huang, Xiaona
Tong, Desheng
Jiang, Chenyu
Zhu, Xiaodan
Wei, Zhipeng
Gong, Tingjie
Jin, Chunhui
author_facet Li, Yuzhen
Huang, Xiaona
Tong, Desheng
Jiang, Chenyu
Zhu, Xiaodan
Wei, Zhipeng
Gong, Tingjie
Jin, Chunhui
author_sort Li, Yuzhen
collection PubMed
description Currently, conventional neoadjuvant therapy or postoperative adjuvant therapy, such as chemotherapy and radiation therapy, can only bring limited survival benefits to gastric cancer (GC). Median survival after palliative chemotherapy is also low, at about 8–10 months. Immunotargeting is a new option for the treatment of GC, but has not been widely replicated. The highly immunosuppressed tumor microenvironment (TME) discounts the efficacy of immunotherapy for GC. Therefore, new strategies are needed to enhance the immune response of the TME. This paper reviewed the relationship between microorganisms and GC, potential links between microorganisms and immunotherapy and research of microorganisms combined immunotherapy.
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spelling pubmed-95119792022-09-27 Relationships among microbiota, gastric cancer, and immunotherapy Li, Yuzhen Huang, Xiaona Tong, Desheng Jiang, Chenyu Zhu, Xiaodan Wei, Zhipeng Gong, Tingjie Jin, Chunhui Front Microbiol Microbiology Currently, conventional neoadjuvant therapy or postoperative adjuvant therapy, such as chemotherapy and radiation therapy, can only bring limited survival benefits to gastric cancer (GC). Median survival after palliative chemotherapy is also low, at about 8–10 months. Immunotargeting is a new option for the treatment of GC, but has not been widely replicated. The highly immunosuppressed tumor microenvironment (TME) discounts the efficacy of immunotherapy for GC. Therefore, new strategies are needed to enhance the immune response of the TME. This paper reviewed the relationship between microorganisms and GC, potential links between microorganisms and immunotherapy and research of microorganisms combined immunotherapy. Frontiers Media S.A. 2022-09-12 /pmc/articles/PMC9511979/ /pubmed/36171746 http://dx.doi.org/10.3389/fmicb.2022.987763 Text en Copyright © 2022 Li, Huang, Tong, Jiang, Zhu, Wei, Gong and Jin. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Li, Yuzhen
Huang, Xiaona
Tong, Desheng
Jiang, Chenyu
Zhu, Xiaodan
Wei, Zhipeng
Gong, Tingjie
Jin, Chunhui
Relationships among microbiota, gastric cancer, and immunotherapy
title Relationships among microbiota, gastric cancer, and immunotherapy
title_full Relationships among microbiota, gastric cancer, and immunotherapy
title_fullStr Relationships among microbiota, gastric cancer, and immunotherapy
title_full_unstemmed Relationships among microbiota, gastric cancer, and immunotherapy
title_short Relationships among microbiota, gastric cancer, and immunotherapy
title_sort relationships among microbiota, gastric cancer, and immunotherapy
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9511979/
https://www.ncbi.nlm.nih.gov/pubmed/36171746
http://dx.doi.org/10.3389/fmicb.2022.987763
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