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Computational model for fetal skeletal defects potentially linked to disruption of retinoic acid signaling

All-trans retinoic acid (ATRA) gradients determine skeletal patterning morphogenesis and can be disrupted by diverse genetic or environmental factors during pregnancy, leading to fetal skeleton defects. Adverse Outcome Pathway (AOP) frameworks for ATRA metabolism, signaling, and homeostasis allow fo...

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Detalles Bibliográficos
Autores principales:	Pierro, Jocylin D., Ahir, Bhavesh K., Baker, Nancy C., Kleinstreuer, Nicole C., Xia, Menghang, Knudsen, Thomas B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9511990/ https://www.ncbi.nlm.nih.gov/pubmed/36172177 http://dx.doi.org/10.3389/fphar.2022.971296

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