Developing HDAC4-Selective Protein Degraders To Investigate the Role of HDAC4 in Huntington’s Disease Pathology

[Image: see text] Huntington’s disease (HD) is a lethal autosomal dominant neurodegenerative disorder resulting from a CAG repeat expansion in the huntingtin (HTT) gene. The product of translation of this gene is a highly aggregation-prone protein containing a polyglutamine tract >35 repeats (mHT...

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Autores principales: Macabuag, Natsuko, Esmieu, William, Breccia, Perla, Jarvis, Rebecca, Blackaby, Wesley, Lazari, Ovadia, Urbonas, Liudvikas, Eznarriaga, Maria, Williams, Rachel, Strijbosch, Annelieke, Van de Bospoort, Rhea, Matthews, Kim, Clissold, Cole, Ladduwahetty, Tammy, Vater, Huw, Heaphy, Patrick, Stafford, Douglas G., Wang, Hong-Jun, Mangette, John E., McAllister, George, Beaumont, Vahri, Vogt, Thomas F., Wilkinson, Hilary A., Doherty, Elizabeth M., Dominguez, Celia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9512014/
https://www.ncbi.nlm.nih.gov/pubmed/36098485
http://dx.doi.org/10.1021/acs.jmedchem.2c01149

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