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Salvia miltiorrhiza in cancer: Potential role in regulating MicroRNAs and epigenetic enzymes

MicroRNAs are small non-coding RNAs that play important roles in gene regulation by influencing the translation and longevity of various target mRNAs and the expression of various target genes as well as by modifying histones and DNA methylation of promoter sites. Consequently, when dysregulated, mi...

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Autores principales: Lu, Meng, Lan, Xintian, Wu, Xi, Fang, Xiaoxue, Zhang, Yegang, Luo, Haoming, Gao, Wenyi, Wu, Donglu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9512245/
https://www.ncbi.nlm.nih.gov/pubmed/36172186
http://dx.doi.org/10.3389/fphar.2022.1008222
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author Lu, Meng
Lan, Xintian
Wu, Xi
Fang, Xiaoxue
Zhang, Yegang
Luo, Haoming
Gao, Wenyi
Wu, Donglu
author_facet Lu, Meng
Lan, Xintian
Wu, Xi
Fang, Xiaoxue
Zhang, Yegang
Luo, Haoming
Gao, Wenyi
Wu, Donglu
author_sort Lu, Meng
collection PubMed
description MicroRNAs are small non-coding RNAs that play important roles in gene regulation by influencing the translation and longevity of various target mRNAs and the expression of various target genes as well as by modifying histones and DNA methylation of promoter sites. Consequently, when dysregulated, microRNAs are involved in the development and progression of a variety of diseases, including cancer, by affecting cell growth, proliferation, differentiation, migration, and apoptosis. Preparations from the dried root and rhizome of Salvia miltiorrhiza Bge (Lamiaceae), also known as red sage or danshen, are widely used for treating cardiovascular diseases. Accumulating data suggest that certain bioactive constituents of this plant, particularly tanshinones, have broad antitumor effects by interfering with microRNAs and epigenetic enzymes. This paper reviews the evidence for the antineoplastic activities of S. miltiorrhiza constituents by causing or promoting cell cycle arrest, apoptosis, autophagy, epithelial-mesenchymal transition, angiogenesis, and epigenetic changes to provide an outlook on their future roles in the treatment of cancer, both alone and in combination with other modalities.
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spelling pubmed-95122452022-09-27 Salvia miltiorrhiza in cancer: Potential role in regulating MicroRNAs and epigenetic enzymes Lu, Meng Lan, Xintian Wu, Xi Fang, Xiaoxue Zhang, Yegang Luo, Haoming Gao, Wenyi Wu, Donglu Front Pharmacol Pharmacology MicroRNAs are small non-coding RNAs that play important roles in gene regulation by influencing the translation and longevity of various target mRNAs and the expression of various target genes as well as by modifying histones and DNA methylation of promoter sites. Consequently, when dysregulated, microRNAs are involved in the development and progression of a variety of diseases, including cancer, by affecting cell growth, proliferation, differentiation, migration, and apoptosis. Preparations from the dried root and rhizome of Salvia miltiorrhiza Bge (Lamiaceae), also known as red sage or danshen, are widely used for treating cardiovascular diseases. Accumulating data suggest that certain bioactive constituents of this plant, particularly tanshinones, have broad antitumor effects by interfering with microRNAs and epigenetic enzymes. This paper reviews the evidence for the antineoplastic activities of S. miltiorrhiza constituents by causing or promoting cell cycle arrest, apoptosis, autophagy, epithelial-mesenchymal transition, angiogenesis, and epigenetic changes to provide an outlook on their future roles in the treatment of cancer, both alone and in combination with other modalities. Frontiers Media S.A. 2022-09-12 /pmc/articles/PMC9512245/ /pubmed/36172186 http://dx.doi.org/10.3389/fphar.2022.1008222 Text en Copyright © 2022 Lu, Lan, Wu, Fang, Zhang, Luo, Gao and Wu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Lu, Meng
Lan, Xintian
Wu, Xi
Fang, Xiaoxue
Zhang, Yegang
Luo, Haoming
Gao, Wenyi
Wu, Donglu
Salvia miltiorrhiza in cancer: Potential role in regulating MicroRNAs and epigenetic enzymes
title Salvia miltiorrhiza in cancer: Potential role in regulating MicroRNAs and epigenetic enzymes
title_full Salvia miltiorrhiza in cancer: Potential role in regulating MicroRNAs and epigenetic enzymes
title_fullStr Salvia miltiorrhiza in cancer: Potential role in regulating MicroRNAs and epigenetic enzymes
title_full_unstemmed Salvia miltiorrhiza in cancer: Potential role in regulating MicroRNAs and epigenetic enzymes
title_short Salvia miltiorrhiza in cancer: Potential role in regulating MicroRNAs and epigenetic enzymes
title_sort salvia miltiorrhiza in cancer: potential role in regulating micrornas and epigenetic enzymes
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9512245/
https://www.ncbi.nlm.nih.gov/pubmed/36172186
http://dx.doi.org/10.3389/fphar.2022.1008222
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