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Salvia miltiorrhiza in cancer: Potential role in regulating MicroRNAs and epigenetic enzymes
MicroRNAs are small non-coding RNAs that play important roles in gene regulation by influencing the translation and longevity of various target mRNAs and the expression of various target genes as well as by modifying histones and DNA methylation of promoter sites. Consequently, when dysregulated, mi...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9512245/ https://www.ncbi.nlm.nih.gov/pubmed/36172186 http://dx.doi.org/10.3389/fphar.2022.1008222 |
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author | Lu, Meng Lan, Xintian Wu, Xi Fang, Xiaoxue Zhang, Yegang Luo, Haoming Gao, Wenyi Wu, Donglu |
author_facet | Lu, Meng Lan, Xintian Wu, Xi Fang, Xiaoxue Zhang, Yegang Luo, Haoming Gao, Wenyi Wu, Donglu |
author_sort | Lu, Meng |
collection | PubMed |
description | MicroRNAs are small non-coding RNAs that play important roles in gene regulation by influencing the translation and longevity of various target mRNAs and the expression of various target genes as well as by modifying histones and DNA methylation of promoter sites. Consequently, when dysregulated, microRNAs are involved in the development and progression of a variety of diseases, including cancer, by affecting cell growth, proliferation, differentiation, migration, and apoptosis. Preparations from the dried root and rhizome of Salvia miltiorrhiza Bge (Lamiaceae), also known as red sage or danshen, are widely used for treating cardiovascular diseases. Accumulating data suggest that certain bioactive constituents of this plant, particularly tanshinones, have broad antitumor effects by interfering with microRNAs and epigenetic enzymes. This paper reviews the evidence for the antineoplastic activities of S. miltiorrhiza constituents by causing or promoting cell cycle arrest, apoptosis, autophagy, epithelial-mesenchymal transition, angiogenesis, and epigenetic changes to provide an outlook on their future roles in the treatment of cancer, both alone and in combination with other modalities. |
format | Online Article Text |
id | pubmed-9512245 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-95122452022-09-27 Salvia miltiorrhiza in cancer: Potential role in regulating MicroRNAs and epigenetic enzymes Lu, Meng Lan, Xintian Wu, Xi Fang, Xiaoxue Zhang, Yegang Luo, Haoming Gao, Wenyi Wu, Donglu Front Pharmacol Pharmacology MicroRNAs are small non-coding RNAs that play important roles in gene regulation by influencing the translation and longevity of various target mRNAs and the expression of various target genes as well as by modifying histones and DNA methylation of promoter sites. Consequently, when dysregulated, microRNAs are involved in the development and progression of a variety of diseases, including cancer, by affecting cell growth, proliferation, differentiation, migration, and apoptosis. Preparations from the dried root and rhizome of Salvia miltiorrhiza Bge (Lamiaceae), also known as red sage or danshen, are widely used for treating cardiovascular diseases. Accumulating data suggest that certain bioactive constituents of this plant, particularly tanshinones, have broad antitumor effects by interfering with microRNAs and epigenetic enzymes. This paper reviews the evidence for the antineoplastic activities of S. miltiorrhiza constituents by causing or promoting cell cycle arrest, apoptosis, autophagy, epithelial-mesenchymal transition, angiogenesis, and epigenetic changes to provide an outlook on their future roles in the treatment of cancer, both alone and in combination with other modalities. Frontiers Media S.A. 2022-09-12 /pmc/articles/PMC9512245/ /pubmed/36172186 http://dx.doi.org/10.3389/fphar.2022.1008222 Text en Copyright © 2022 Lu, Lan, Wu, Fang, Zhang, Luo, Gao and Wu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pharmacology Lu, Meng Lan, Xintian Wu, Xi Fang, Xiaoxue Zhang, Yegang Luo, Haoming Gao, Wenyi Wu, Donglu Salvia miltiorrhiza in cancer: Potential role in regulating MicroRNAs and epigenetic enzymes |
title |
Salvia miltiorrhiza in cancer: Potential role in regulating MicroRNAs and epigenetic enzymes |
title_full |
Salvia miltiorrhiza in cancer: Potential role in regulating MicroRNAs and epigenetic enzymes |
title_fullStr |
Salvia miltiorrhiza in cancer: Potential role in regulating MicroRNAs and epigenetic enzymes |
title_full_unstemmed |
Salvia miltiorrhiza in cancer: Potential role in regulating MicroRNAs and epigenetic enzymes |
title_short |
Salvia miltiorrhiza in cancer: Potential role in regulating MicroRNAs and epigenetic enzymes |
title_sort | salvia miltiorrhiza in cancer: potential role in regulating micrornas and epigenetic enzymes |
topic | Pharmacology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9512245/ https://www.ncbi.nlm.nih.gov/pubmed/36172186 http://dx.doi.org/10.3389/fphar.2022.1008222 |
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