Non-surgical Management of Locally Advanced Basal Cell Carcinoma of the Upper Extremity With Vismodegib

Basal cell carcinoma (BCC) is a common skin malignancy that can present reconstructive challenges in patients with locally advanced diseases of the extremities. This article highlights three cases of locally advanced BCC of the extremities managed with vismodegib (Erivedge, Genentech). Vismodegib is...

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Autores principales: Swisher, Austin R, Landau, Mark J, Davila, Allison B, Davila, Armando A, Zagaynov, Caryn, Bobbitt, Christopher A, Leong, Darren S, Chang, Alexander Y, Chang, Walter T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
Dermatology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9512297/
https://www.ncbi.nlm.nih.gov/pubmed/36176836
http://dx.doi.org/10.7759/cureus.28479
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author Swisher, Austin R
Landau, Mark J
Davila, Allison B
Davila, Armando A
Zagaynov, Caryn
Bobbitt, Christopher A
Leong, Darren S
Chang, Alexander Y
Chang, Walter T
author_facet Swisher, Austin R
Landau, Mark J
Davila, Allison B
Davila, Armando A
Zagaynov, Caryn
Bobbitt, Christopher A
Leong, Darren S
Chang, Alexander Y
Chang, Walter T
author_sort Swisher, Austin R
collection PubMed
description Basal cell carcinoma (BCC) is a common skin malignancy that can present reconstructive challenges in patients with locally advanced diseases of the extremities. This article highlights three cases of locally advanced BCC of the extremities managed with vismodegib (Erivedge, Genentech). Vismodegib is a sonic hedgehog pathway (Shh) inhibitor approved by the FDA for use in metastatic or recurrent BCC. All three patients in our case series demonstrated significant clinical responses with reductions in tumor size which obviated the need for complex reconstructive surgery or amputation.
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spelling pubmed-95122972022-09-28 Non-surgical Management of Locally Advanced Basal Cell Carcinoma of the Upper Extremity With Vismodegib Swisher, Austin R Landau, Mark J Davila, Allison B Davila, Armando A Zagaynov, Caryn Bobbitt, Christopher A Leong, Darren S Chang, Alexander Y Chang, Walter T Cureus Dermatology Basal cell carcinoma (BCC) is a common skin malignancy that can present reconstructive challenges in patients with locally advanced diseases of the extremities. This article highlights three cases of locally advanced BCC of the extremities managed with vismodegib (Erivedge, Genentech). Vismodegib is a sonic hedgehog pathway (Shh) inhibitor approved by the FDA for use in metastatic or recurrent BCC. All three patients in our case series demonstrated significant clinical responses with reductions in tumor size which obviated the need for complex reconstructive surgery or amputation. Cureus 2022-08-27 /pmc/articles/PMC9512297/ /pubmed/36176836 http://dx.doi.org/10.7759/cureus.28479 Text en Copyright © 2022, Swisher et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Dermatology
Swisher, Austin R
Landau, Mark J
Davila, Allison B
Davila, Armando A
Zagaynov, Caryn
Bobbitt, Christopher A
Leong, Darren S
Chang, Alexander Y
Chang, Walter T
Non-surgical Management of Locally Advanced Basal Cell Carcinoma of the Upper Extremity With Vismodegib
title Non-surgical Management of Locally Advanced Basal Cell Carcinoma of the Upper Extremity With Vismodegib
title_full Non-surgical Management of Locally Advanced Basal Cell Carcinoma of the Upper Extremity With Vismodegib
title_fullStr Non-surgical Management of Locally Advanced Basal Cell Carcinoma of the Upper Extremity With Vismodegib
title_full_unstemmed Non-surgical Management of Locally Advanced Basal Cell Carcinoma of the Upper Extremity With Vismodegib
title_short Non-surgical Management of Locally Advanced Basal Cell Carcinoma of the Upper Extremity With Vismodegib
title_sort non-surgical management of locally advanced basal cell carcinoma of the upper extremity with vismodegib
topic Dermatology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9512297/
https://www.ncbi.nlm.nih.gov/pubmed/36176836
http://dx.doi.org/10.7759/cureus.28479
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