Neutrophil-mediated fibroblast-tumor cell il-6/stat-3 signaling underlies the association between neutrophil-to-lymphocyte ratio dynamics and chemotherapy response in localized pancreatic cancer: A hybrid clinical-preclinical study

BACKGROUND: Partial/complete pathologic response following neoadjuvant chemotherapy (NAC) in pancreatic cancer (PDAC) patients undergoing pancreatectomy is associated with improved survival. We sought to determine whether neutrophil-to-lymphocyte ratio (NLR) dynamics predict pathologic response foll...

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Detalles Bibliográficos
Autores principales: de Castro Silva, Iago, Bianchi, Anna, Deshpande, Nilesh U, Sharma, Prateek, Mehra, Siddharth, Garrido, Vanessa Tonin, Saigh, Shannon Jacqueline, England, Jonathan, Hosein, Peter Joel, Kwon, Deukwoo, Merchant, Nipun B, Datta, Jashodeep
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Immunology and Inflammation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9512403/
https://www.ncbi.nlm.nih.gov/pubmed/36107485
http://dx.doi.org/10.7554/eLife.78921

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