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Fip1 is a multivalent interaction scaffold for processing factors in human mRNA 3′ end biogenesis

3′ end formation of most eukaryotic mRNAs is dependent on the assembly of a ~1.5 MDa multiprotein complex, that catalyzes the coupled reaction of pre-mRNA cleavage and polyadenylation. In mammals, the cleavage and polyadenylation specificity factor (CPSF) constitutes the core of the 3′ end processin...

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Detalles Bibliográficos
Autores principales:	Muckenfuss, Lena Maria, Migenda Herranz, Anabel Carmen, Boneberg, Franziska Maria, Clerici, Marcello, Jinek, Martin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2022
Materias:	Chromosomes and Gene Expression
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9512404/ https://www.ncbi.nlm.nih.gov/pubmed/36073787 http://dx.doi.org/10.7554/eLife.80332

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