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Current knowledge of leptin in wound healing: A collaborative review
Efficacious wound healing is still a major concern for global healthcare due to the unsatisfactory outcomes under the current treatments. Leptin, an adipocyte-derived hormone, mainly acts in the hypothalamus and plays crucial roles in various biological processes. Recently, an increasing number of r...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9512445/ https://www.ncbi.nlm.nih.gov/pubmed/36172174 http://dx.doi.org/10.3389/fphar.2022.968142 |
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author | Yuan, Chi Liao, Jian Zheng, Liying Ding, Lingzhi Teng, Xiao Lin, Xuesong Wang, Le |
author_facet | Yuan, Chi Liao, Jian Zheng, Liying Ding, Lingzhi Teng, Xiao Lin, Xuesong Wang, Le |
author_sort | Yuan, Chi |
collection | PubMed |
description | Efficacious wound healing is still a major concern for global healthcare due to the unsatisfactory outcomes under the current treatments. Leptin, an adipocyte-derived hormone, mainly acts in the hypothalamus and plays crucial roles in various biological processes. Recently, an increasing number of researches have shown that leptin played an important role in the wound healing process. In this review, we presented a first attempt to capture the current knowledge on the association between leptin and wound healing. After a comprehensive review, the molecular mechanisms underlying leptin in wound healing were speculated to be correlated to the regulation of inflammation of the macrophage and lymphocytes, angiogenesis, re-epithelialization, proliferation, and differentiation of fibroblasts. The affected genes and the signal pathways were multiple. For example, leptin was reported to ameliorate wound healing by its anti-inflammatory action, which might be correlated to the activation STAT1 and STAT3 via p38 MAPK or JAK2. However, the understanding of the specific role in each process (e.g., inflammatory, proliferative, and maturation phase) of wound repair is not entirely clear, and further studies are still warranted in both macrostructural and microscale factors. Therefore, identifying and validating the biological mechanisms of leptin in wound healing is of great significance to develop potential therapeutic targets for the treatment of wound healing in clinical practice. |
format | Online Article Text |
id | pubmed-9512445 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-95124452022-09-27 Current knowledge of leptin in wound healing: A collaborative review Yuan, Chi Liao, Jian Zheng, Liying Ding, Lingzhi Teng, Xiao Lin, Xuesong Wang, Le Front Pharmacol Pharmacology Efficacious wound healing is still a major concern for global healthcare due to the unsatisfactory outcomes under the current treatments. Leptin, an adipocyte-derived hormone, mainly acts in the hypothalamus and plays crucial roles in various biological processes. Recently, an increasing number of researches have shown that leptin played an important role in the wound healing process. In this review, we presented a first attempt to capture the current knowledge on the association between leptin and wound healing. After a comprehensive review, the molecular mechanisms underlying leptin in wound healing were speculated to be correlated to the regulation of inflammation of the macrophage and lymphocytes, angiogenesis, re-epithelialization, proliferation, and differentiation of fibroblasts. The affected genes and the signal pathways were multiple. For example, leptin was reported to ameliorate wound healing by its anti-inflammatory action, which might be correlated to the activation STAT1 and STAT3 via p38 MAPK or JAK2. However, the understanding of the specific role in each process (e.g., inflammatory, proliferative, and maturation phase) of wound repair is not entirely clear, and further studies are still warranted in both macrostructural and microscale factors. Therefore, identifying and validating the biological mechanisms of leptin in wound healing is of great significance to develop potential therapeutic targets for the treatment of wound healing in clinical practice. Frontiers Media S.A. 2022-09-12 /pmc/articles/PMC9512445/ /pubmed/36172174 http://dx.doi.org/10.3389/fphar.2022.968142 Text en Copyright © 2022 Yuan, Liao, Zheng, Ding, Teng, Lin and Wang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pharmacology Yuan, Chi Liao, Jian Zheng, Liying Ding, Lingzhi Teng, Xiao Lin, Xuesong Wang, Le Current knowledge of leptin in wound healing: A collaborative review |
title | Current knowledge of leptin in wound healing: A collaborative review |
title_full | Current knowledge of leptin in wound healing: A collaborative review |
title_fullStr | Current knowledge of leptin in wound healing: A collaborative review |
title_full_unstemmed | Current knowledge of leptin in wound healing: A collaborative review |
title_short | Current knowledge of leptin in wound healing: A collaborative review |
title_sort | current knowledge of leptin in wound healing: a collaborative review |
topic | Pharmacology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9512445/ https://www.ncbi.nlm.nih.gov/pubmed/36172174 http://dx.doi.org/10.3389/fphar.2022.968142 |
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