Hepatic patatin‐like phospholipase domain‐containing 3 levels are increased in I148M risk allele carriers and correlate with NAFLD in humans

In nonalcoholic fatty liver disease (NAFLD) the patatin‐like phospholipase domain‐containing 3 (PNPLA3) rs738409 variant is a contributor. In mice, the Pnpla3 148M variant accumulates on lipid droplets and probably leads to sequestration of a lipase cofactor leading to impaired mobilization of trigl...

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Detalles Bibliográficos
Autores principales: Ericson, Elke, Bergenholm, Linnéa, Andréasson, Anne‐Christine, Dix, Carly I., Knöchel, Jane, Hansson, Sara F., Lee, Richard, Schumi, Jennifer, Antonsson, Madeleine, Fjellström, Ola, Nasr, Patrik, Liljeblad, Mathias, Carlsson, Björn, Kechagias, Stergios, Lindén, Daniel, Ekstedt, Mattias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9512469/
https://www.ncbi.nlm.nih.gov/pubmed/35833455
http://dx.doi.org/10.1002/hep4.2032

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9512469/
https://www.ncbi.nlm.nih.gov/pubmed/35833455
http://dx.doi.org/10.1002/hep4.2032

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