Cargando…
GCKIII kinases in lipotoxicity: Roles in NAFLD and beyond
Nonalcoholic fatty liver disease (NAFLD) is defined by excessive accumulation of lipid droplets within hepatocytes. The STE20‐type kinases comprising the germinal center kinase III (GCKIII) subfamily – MST3, MST4, and STK25 – decorate intrahepatocellular lipid droplets and have recently emerged as c...
Autores principales: | Mahlapuu, Margit, Caputo, Mara, Xia, Ying, Cansby, Emmelie |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9512487/ https://www.ncbi.nlm.nih.gov/pubmed/35641240 http://dx.doi.org/10.1002/hep4.2013 |
Ejemplares similares
-
Silencing of STE20-type kinase TAOK1 confers protection against hepatocellular lipotoxicity through metabolic rewiring
por: Xia, Ying, et al.
Publicado: (2023) -
Depletion of protein kinase STK25 ameliorates renal lipotoxicity and protects against diabetic kidney disease
por: Cansby, Emmelie, et al.
Publicado: (2020) -
STE20‐Type Protein Kinase MST4 Controls NAFLD Progression by Regulating Lipid Droplet Dynamics and Metabolic Stress in Hepatocytes
por: Caputo, Mara, et al.
Publicado: (2021) -
Knockout of STE20-type kinase TAOK3 does not attenuate diet-induced NAFLD development in mice
por: Xia, Ying, et al.
Publicado: (2023) -
Inhibition of MAP4K4 signaling initiates metabolic reprogramming to protect hepatocytes from lipotoxic damage
por: Anand, Sumit Kumar, et al.
Publicado: (2022)