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A Standardized Nonvisual Behavioral Event Is Broadcasted Homogeneously across Cortical Visual Areas without Modulating Visual Responses

Multiple recent studies have shown that motor activity greatly impacts the activity of primary sensory areas like V1. Yet, the role of this motor related activity in sensory processing is still unclear. Here, we dissect how these behavior signals are broadcast to different layers and areas of the vi...

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Autores principales: Ramadan, Mahdi, Lee, Eric Kenji, de Vries, Saskia, Caldejon, Shiella, Kato, India, Roll, Kate, Griffin, Fiona, Nguyen, Thuyanh V., Larkin, Josh, Rhoads, Paul, Mace, Kyla, Kriedberg, Ali, Howard, Robert, Berbesque, Nathan, Lecoq, Jérôme
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Neuroscience 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9512619/
https://www.ncbi.nlm.nih.gov/pubmed/36635937
http://dx.doi.org/10.1523/ENEURO.0491-21.2022
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author Ramadan, Mahdi
Lee, Eric Kenji
de Vries, Saskia
Caldejon, Shiella
Kato, India
Roll, Kate
Griffin, Fiona
Nguyen, Thuyanh V.
Larkin, Josh
Rhoads, Paul
Mace, Kyla
Kriedberg, Ali
Howard, Robert
Berbesque, Nathan
Lecoq, Jérôme
author_facet Ramadan, Mahdi
Lee, Eric Kenji
de Vries, Saskia
Caldejon, Shiella
Kato, India
Roll, Kate
Griffin, Fiona
Nguyen, Thuyanh V.
Larkin, Josh
Rhoads, Paul
Mace, Kyla
Kriedberg, Ali
Howard, Robert
Berbesque, Nathan
Lecoq, Jérôme
author_sort Ramadan, Mahdi
collection PubMed
description Multiple recent studies have shown that motor activity greatly impacts the activity of primary sensory areas like V1. Yet, the role of this motor related activity in sensory processing is still unclear. Here, we dissect how these behavior signals are broadcast to different layers and areas of the visual cortex. To do so, we leveraged a standardized and spontaneous behavioral fidget event in passively viewing mice. Importantly, this behavior event had no relevance to any ongoing task allowing us to compare its neuronal correlates with visually relevant behaviors (e.g., running). A large two-photon Ca(2+) imaging database of neuronal responses uncovered four neural response types during fidgets that were consistent in their proportion and response patterns across all visual areas and layers of the visual cortex. Indeed, the layer and area identity could not be decoded above chance level based only on neuronal recordings. In contrast to running behavior, fidget evoked neural responses that were independent to visual processing. The broad availability of visually orthogonal standardized behavior signals could be a key component in how the cortex selects, learns and binds local sensory information with motor outputs. Contrary to behaviorally relevant motor outputs, irrelevant motor signals could project to separate local neural subspaces.
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spelling pubmed-95126192022-09-27 A Standardized Nonvisual Behavioral Event Is Broadcasted Homogeneously across Cortical Visual Areas without Modulating Visual Responses Ramadan, Mahdi Lee, Eric Kenji de Vries, Saskia Caldejon, Shiella Kato, India Roll, Kate Griffin, Fiona Nguyen, Thuyanh V. Larkin, Josh Rhoads, Paul Mace, Kyla Kriedberg, Ali Howard, Robert Berbesque, Nathan Lecoq, Jérôme eNeuro Research Article: New Research Multiple recent studies have shown that motor activity greatly impacts the activity of primary sensory areas like V1. Yet, the role of this motor related activity in sensory processing is still unclear. Here, we dissect how these behavior signals are broadcast to different layers and areas of the visual cortex. To do so, we leveraged a standardized and spontaneous behavioral fidget event in passively viewing mice. Importantly, this behavior event had no relevance to any ongoing task allowing us to compare its neuronal correlates with visually relevant behaviors (e.g., running). A large two-photon Ca(2+) imaging database of neuronal responses uncovered four neural response types during fidgets that were consistent in their proportion and response patterns across all visual areas and layers of the visual cortex. Indeed, the layer and area identity could not be decoded above chance level based only on neuronal recordings. In contrast to running behavior, fidget evoked neural responses that were independent to visual processing. The broad availability of visually orthogonal standardized behavior signals could be a key component in how the cortex selects, learns and binds local sensory information with motor outputs. Contrary to behaviorally relevant motor outputs, irrelevant motor signals could project to separate local neural subspaces. Society for Neuroscience 2022-09-21 /pmc/articles/PMC9512619/ /pubmed/36635937 http://dx.doi.org/10.1523/ENEURO.0491-21.2022 Text en Copyright © 2022 Ramadan et al. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
spellingShingle Research Article: New Research
Ramadan, Mahdi
Lee, Eric Kenji
de Vries, Saskia
Caldejon, Shiella
Kato, India
Roll, Kate
Griffin, Fiona
Nguyen, Thuyanh V.
Larkin, Josh
Rhoads, Paul
Mace, Kyla
Kriedberg, Ali
Howard, Robert
Berbesque, Nathan
Lecoq, Jérôme
A Standardized Nonvisual Behavioral Event Is Broadcasted Homogeneously across Cortical Visual Areas without Modulating Visual Responses
title A Standardized Nonvisual Behavioral Event Is Broadcasted Homogeneously across Cortical Visual Areas without Modulating Visual Responses
title_full A Standardized Nonvisual Behavioral Event Is Broadcasted Homogeneously across Cortical Visual Areas without Modulating Visual Responses
title_fullStr A Standardized Nonvisual Behavioral Event Is Broadcasted Homogeneously across Cortical Visual Areas without Modulating Visual Responses
title_full_unstemmed A Standardized Nonvisual Behavioral Event Is Broadcasted Homogeneously across Cortical Visual Areas without Modulating Visual Responses
title_short A Standardized Nonvisual Behavioral Event Is Broadcasted Homogeneously across Cortical Visual Areas without Modulating Visual Responses
title_sort standardized nonvisual behavioral event is broadcasted homogeneously across cortical visual areas without modulating visual responses
topic Research Article: New Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9512619/
https://www.ncbi.nlm.nih.gov/pubmed/36635937
http://dx.doi.org/10.1523/ENEURO.0491-21.2022
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