Cargando…
Design principles to assemble drug combinations for effective tuberculosis therapy using interpretable pairwise drug response measurements
A challenge in tuberculosis treatment regimen design is the necessity to combine three or more antibiotics. We narrow the prohibitively large search space by breaking down high-order drug combinations into drug pair units. Using pairwise in vitro measurements, we train machine learning models to pre...
| Autores principales: | , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2022
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9512659/ https://www.ncbi.nlm.nih.gov/pubmed/36084643 http://dx.doi.org/10.1016/j.xcrm.2022.100737 |