Autophagic flux restoration of senescent T cells improves antitumor activity of TCR‐engineered T cells

OBJECTIVES: Although adoptive cell therapy with T‐cell receptor‐engineered T cells (TCR‐Ts) has mediated effective antitumor responses in several cancers, senescence of T cells could impair the therapeutic effect of TCR‐Ts. Thus, it is essential to elucidate the characteristics of senescent TCR‐Ts a...

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Detalles Bibliográficos
Autores principales: Zhang, Chaoting, Sun, Yizhe, Li, Shance, Shen, Luyan, Teng, Xia, Xiao, Yefei, Zhou, Ping, Lu, Zheming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9512689/
https://www.ncbi.nlm.nih.gov/pubmed/36188121
http://dx.doi.org/10.1002/cti2.1419

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9512689/
https://www.ncbi.nlm.nih.gov/pubmed/36188121
http://dx.doi.org/10.1002/cti2.1419

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