A dimeric proteomimetic prevents SARS-CoV-2 infection by dimerizing the spike protein

Protein tertiary structure mimetics are valuable tools to target large protein–protein interaction interfaces. Here, we demonstrate a strategy for designing dimeric helix-hairpin motifs from a previously reported three-helix-bundle miniprotein that targets the receptor-binding domain (RBD) of severe...

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Detalles Bibliográficos
Autores principales: Khatri, Bhavesh, Pramanick, Ishika, Malladi, Sameer Kumar, Rajmani, Raju S., Kumar, Sahil, Ghosh, Pritha, Sengupta, Nayanika, Rahisuddin, R., Kumar, Narender, Kumaran, S., Ringe, Rajesh P., Varadarajan, Raghavan, Dutta, Somnath, Chatterjee, Jayanta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9512702/
https://www.ncbi.nlm.nih.gov/pubmed/35654847
http://dx.doi.org/10.1038/s41589-022-01060-0

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