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Pulse pressure and the risk of renal hyperfiltration in young adults: Results from Korea National Health and Nutrition Examination Survey (2010–2019)

BACKGROUND: High pulse pressure (PP) is associated with increased risk of decline of kidney function. However, little is known about the association between PP and RHF in young adults. This study aimed to evaluate the association between PP and RHF in healthy young adults. METHODS: Data were retriev...

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Autores principales: Yang, Eunji, Park, Sang Ho, Lee, Seoyoung, Oh, Donghwan, Choi, Hoon Young, Park, Hyeong Cheon, Jhee, Jong Hyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9513024/
https://www.ncbi.nlm.nih.gov/pubmed/36177333
http://dx.doi.org/10.3389/fmed.2022.911267
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author Yang, Eunji
Park, Sang Ho
Lee, Seoyoung
Oh, Donghwan
Choi, Hoon Young
Park, Hyeong Cheon
Jhee, Jong Hyun
author_facet Yang, Eunji
Park, Sang Ho
Lee, Seoyoung
Oh, Donghwan
Choi, Hoon Young
Park, Hyeong Cheon
Jhee, Jong Hyun
author_sort Yang, Eunji
collection PubMed
description BACKGROUND: High pulse pressure (PP) is associated with increased risk of decline of kidney function. However, little is known about the association between PP and RHF in young adults. This study aimed to evaluate the association between PP and RHF in healthy young adults. METHODS: Data were retrieved from the Korea National Health and Nutrition Examination Survey from 2010 to 2019. A total of 10,365 participants aged 19–39 years with no hypertension and normal kidney function were analyzed. RHF was defined as logarithm transformed estimated glomerular filtration rate (eGFR) with residuals >90th percentile after adjustment for sex, logarithm transformed age, weight, and height. Participants were divided into tertile based on PP levels. RESULTS: The prevalence of RHF was higher in higher PP tertile group (6.6, 10.5, and 12.7% in T1, T2, and T3; P for trend < 0.001). In multivariable logistic regression analyses, the risk for RHF was increased in higher PP tertiles compared to the lowest tertile [odds ratio (OR), 1.42; 95% confidence interval (CI), 1.19–1.69 in T2; OR, 1.44; 95% CI, 1.20–1.73 in T3]. When PP levels were treated as continuous variable, the risk of RHF was increased 2.36 per 1.0 increase of PP (P < 0.001). In subgroup analyses stratified sex, histories of diabetes or dyslipidemia, and isolated systolic hypertension or isolated diastolic hypertension, there were no significant interactions with PP for the risk for RHF, suggesting that high PP was associated with increased risk of RHF regardless of subgroups. However, the subgroup with BMI showed significant interaction with PP for the risk of RHF, indicating that participants with BMI ≥ 25 kg/m(2) were at higher risk of RHF with increasing PP levels than those with BMI < 25 kg/m(2) (OR, 1.89; 95% CI, 1.25–2.87 in BMI < 25 kg/m(2); OR, 3.16; 95% CI, 1.74–5.73 in BMI ≥ 25 kg/m(2); P for interaction = 0.01). CONCLUSION: High PP is associated with an increased risk of RHF in healthy young adults and this association is prominent in obese young adults. The assessment of PP and associated RHF may give benefit to early detect the potential risk of CKD development in young adults.
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spelling pubmed-95130242022-09-28 Pulse pressure and the risk of renal hyperfiltration in young adults: Results from Korea National Health and Nutrition Examination Survey (2010–2019) Yang, Eunji Park, Sang Ho Lee, Seoyoung Oh, Donghwan Choi, Hoon Young Park, Hyeong Cheon Jhee, Jong Hyun Front Med (Lausanne) Medicine BACKGROUND: High pulse pressure (PP) is associated with increased risk of decline of kidney function. However, little is known about the association between PP and RHF in young adults. This study aimed to evaluate the association between PP and RHF in healthy young adults. METHODS: Data were retrieved from the Korea National Health and Nutrition Examination Survey from 2010 to 2019. A total of 10,365 participants aged 19–39 years with no hypertension and normal kidney function were analyzed. RHF was defined as logarithm transformed estimated glomerular filtration rate (eGFR) with residuals >90th percentile after adjustment for sex, logarithm transformed age, weight, and height. Participants were divided into tertile based on PP levels. RESULTS: The prevalence of RHF was higher in higher PP tertile group (6.6, 10.5, and 12.7% in T1, T2, and T3; P for trend < 0.001). In multivariable logistic regression analyses, the risk for RHF was increased in higher PP tertiles compared to the lowest tertile [odds ratio (OR), 1.42; 95% confidence interval (CI), 1.19–1.69 in T2; OR, 1.44; 95% CI, 1.20–1.73 in T3]. When PP levels were treated as continuous variable, the risk of RHF was increased 2.36 per 1.0 increase of PP (P < 0.001). In subgroup analyses stratified sex, histories of diabetes or dyslipidemia, and isolated systolic hypertension or isolated diastolic hypertension, there were no significant interactions with PP for the risk for RHF, suggesting that high PP was associated with increased risk of RHF regardless of subgroups. However, the subgroup with BMI showed significant interaction with PP for the risk of RHF, indicating that participants with BMI ≥ 25 kg/m(2) were at higher risk of RHF with increasing PP levels than those with BMI < 25 kg/m(2) (OR, 1.89; 95% CI, 1.25–2.87 in BMI < 25 kg/m(2); OR, 3.16; 95% CI, 1.74–5.73 in BMI ≥ 25 kg/m(2); P for interaction = 0.01). CONCLUSION: High PP is associated with an increased risk of RHF in healthy young adults and this association is prominent in obese young adults. The assessment of PP and associated RHF may give benefit to early detect the potential risk of CKD development in young adults. Frontiers Media S.A. 2022-09-13 /pmc/articles/PMC9513024/ /pubmed/36177333 http://dx.doi.org/10.3389/fmed.2022.911267 Text en Copyright © 2022 Yang, Park, Lee, Oh, Choi, Park and Jhee. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Yang, Eunji
Park, Sang Ho
Lee, Seoyoung
Oh, Donghwan
Choi, Hoon Young
Park, Hyeong Cheon
Jhee, Jong Hyun
Pulse pressure and the risk of renal hyperfiltration in young adults: Results from Korea National Health and Nutrition Examination Survey (2010–2019)
title Pulse pressure and the risk of renal hyperfiltration in young adults: Results from Korea National Health and Nutrition Examination Survey (2010–2019)
title_full Pulse pressure and the risk of renal hyperfiltration in young adults: Results from Korea National Health and Nutrition Examination Survey (2010–2019)
title_fullStr Pulse pressure and the risk of renal hyperfiltration in young adults: Results from Korea National Health and Nutrition Examination Survey (2010–2019)
title_full_unstemmed Pulse pressure and the risk of renal hyperfiltration in young adults: Results from Korea National Health and Nutrition Examination Survey (2010–2019)
title_short Pulse pressure and the risk of renal hyperfiltration in young adults: Results from Korea National Health and Nutrition Examination Survey (2010–2019)
title_sort pulse pressure and the risk of renal hyperfiltration in young adults: results from korea national health and nutrition examination survey (2010–2019)
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9513024/
https://www.ncbi.nlm.nih.gov/pubmed/36177333
http://dx.doi.org/10.3389/fmed.2022.911267
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