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Center-surround interactions underlie bipolar cell motion sensitivity in the mouse retina

Motion sensing is a critical aspect of vision. We studied the representation of motion in mouse retinal bipolar cells and found that some bipolar cells are radially direction selective, preferring the origin of small object motion trajectories. Using a glutamate sensor, we directly observed bipolar...

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Autores principales: Strauss, Sarah, Korympidou, Maria M., Ran, Yanli, Franke, Katrin, Schubert, Timm, Baden, Tom, Berens, Philipp, Euler, Thomas, Vlasits, Anna L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9513071/
https://www.ncbi.nlm.nih.gov/pubmed/36163124
http://dx.doi.org/10.1038/s41467-022-32762-7
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author Strauss, Sarah
Korympidou, Maria M.
Ran, Yanli
Franke, Katrin
Schubert, Timm
Baden, Tom
Berens, Philipp
Euler, Thomas
Vlasits, Anna L.
author_facet Strauss, Sarah
Korympidou, Maria M.
Ran, Yanli
Franke, Katrin
Schubert, Timm
Baden, Tom
Berens, Philipp
Euler, Thomas
Vlasits, Anna L.
author_sort Strauss, Sarah
collection PubMed
description Motion sensing is a critical aspect of vision. We studied the representation of motion in mouse retinal bipolar cells and found that some bipolar cells are radially direction selective, preferring the origin of small object motion trajectories. Using a glutamate sensor, we directly observed bipolar cells synaptic output and found that there are radial direction selective and non-selective bipolar cell types, the majority being selective, and that radial direction selectivity relies on properties of the center-surround receptive field. We used these bipolar cell receptive fields along with connectomics to design biophysical models of downstream cells. The models and additional experiments demonstrated that bipolar cells pass radial direction selective excitation to starburst amacrine cells, which contributes to their directional tuning. As bipolar cells provide excitation to most amacrine and ganglion cells, their radial direction selectivity may contribute to motion processing throughout the visual system.
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spelling pubmed-95130712022-09-28 Center-surround interactions underlie bipolar cell motion sensitivity in the mouse retina Strauss, Sarah Korympidou, Maria M. Ran, Yanli Franke, Katrin Schubert, Timm Baden, Tom Berens, Philipp Euler, Thomas Vlasits, Anna L. Nat Commun Article Motion sensing is a critical aspect of vision. We studied the representation of motion in mouse retinal bipolar cells and found that some bipolar cells are radially direction selective, preferring the origin of small object motion trajectories. Using a glutamate sensor, we directly observed bipolar cells synaptic output and found that there are radial direction selective and non-selective bipolar cell types, the majority being selective, and that radial direction selectivity relies on properties of the center-surround receptive field. We used these bipolar cell receptive fields along with connectomics to design biophysical models of downstream cells. The models and additional experiments demonstrated that bipolar cells pass radial direction selective excitation to starburst amacrine cells, which contributes to their directional tuning. As bipolar cells provide excitation to most amacrine and ganglion cells, their radial direction selectivity may contribute to motion processing throughout the visual system. Nature Publishing Group UK 2022-09-26 /pmc/articles/PMC9513071/ /pubmed/36163124 http://dx.doi.org/10.1038/s41467-022-32762-7 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Strauss, Sarah
Korympidou, Maria M.
Ran, Yanli
Franke, Katrin
Schubert, Timm
Baden, Tom
Berens, Philipp
Euler, Thomas
Vlasits, Anna L.
Center-surround interactions underlie bipolar cell motion sensitivity in the mouse retina
title Center-surround interactions underlie bipolar cell motion sensitivity in the mouse retina
title_full Center-surround interactions underlie bipolar cell motion sensitivity in the mouse retina
title_fullStr Center-surround interactions underlie bipolar cell motion sensitivity in the mouse retina
title_full_unstemmed Center-surround interactions underlie bipolar cell motion sensitivity in the mouse retina
title_short Center-surround interactions underlie bipolar cell motion sensitivity in the mouse retina
title_sort center-surround interactions underlie bipolar cell motion sensitivity in the mouse retina
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9513071/
https://www.ncbi.nlm.nih.gov/pubmed/36163124
http://dx.doi.org/10.1038/s41467-022-32762-7
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