Airway basal cells show a dedifferentiated KRT17(high)Phenotype and promote fibrosis in idiopathic pulmonary fibrosis

Idiopathic pulmonary fibrosis (IPF) is a fatal disease with limited treatment options. In this study, we focus on the properties of airway basal cells (ABC) obtained from patients with IPF (IPF-ABC). Single cell RNA sequencing (scRNAseq) of bronchial brushes revealed extensive reprogramming of IPF-A...

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Detalles Bibliográficos
Autores principales: Jaeger, Benedikt, Schupp, Jonas Christian, Plappert, Linda, Terwolbeck, Oliver, Artysh, Nataliia, Kayser, Gian, Engelhard, Peggy, Adams, Taylor Sterling, Zweigerdt, Robert, Kempf, Henning, Lienenklaus, Stefan, Garrels, Wiebke, Nazarenko, Irina, Jonigk, Danny, Wygrecka, Malgorzata, Klatt, Denise, Schambach, Axel, Kaminski, Naftali, Prasse, Antje
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9513076/
https://www.ncbi.nlm.nih.gov/pubmed/36163190
http://dx.doi.org/10.1038/s41467-022-33193-0

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