Organometallic gold(I) and gold(III) complexes for lung cancer treatment

Metal compounds, especially gold complexes, have recently gained increasing attention as possible lung cancer therapeutics. Some gold complexes display not only excellent activity in cisplatin-sensitive lung cancer but also in cisplatin-resistant lung cancer, revealing promising prospects in the dev...

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Detalles Bibliográficos
Autores principales: Zhang, Juzheng, Li, Yanping, Fang, Ronghao, Wei, Wei, Wang, Yong, Jin, Jiamin, Yang, Feng, Chen, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9513137/
https://www.ncbi.nlm.nih.gov/pubmed/36176441
http://dx.doi.org/10.3389/fphar.2022.979951
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author Zhang, Juzheng
Li, Yanping
Fang, Ronghao
Wei, Wei
Wang, Yong
Jin, Jiamin
Yang, Feng
Chen, Jian
author_facet Zhang, Juzheng
Li, Yanping
Fang, Ronghao
Wei, Wei
Wang, Yong
Jin, Jiamin
Yang, Feng
Chen, Jian
author_sort Zhang, Juzheng
collection PubMed
description Metal compounds, especially gold complexes, have recently gained increasing attention as possible lung cancer therapeutics. Some gold complexes display not only excellent activity in cisplatin-sensitive lung cancer but also in cisplatin-resistant lung cancer, revealing promising prospects in the development of novel treatments for lung cancer. This review summarizes examples of anticancer gold(I) and gold (III) complexes for lung cancer treatment, including mechanisms of action and approaches adopted to improve their efficiency. Several excellent examples of gold complexes against lung cancer are highlighted.
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spelling pubmed-95131372022-09-28 Organometallic gold(I) and gold(III) complexes for lung cancer treatment Zhang, Juzheng Li, Yanping Fang, Ronghao Wei, Wei Wang, Yong Jin, Jiamin Yang, Feng Chen, Jian Front Pharmacol Pharmacology Metal compounds, especially gold complexes, have recently gained increasing attention as possible lung cancer therapeutics. Some gold complexes display not only excellent activity in cisplatin-sensitive lung cancer but also in cisplatin-resistant lung cancer, revealing promising prospects in the development of novel treatments for lung cancer. This review summarizes examples of anticancer gold(I) and gold (III) complexes for lung cancer treatment, including mechanisms of action and approaches adopted to improve their efficiency. Several excellent examples of gold complexes against lung cancer are highlighted. Frontiers Media S.A. 2022-09-13 /pmc/articles/PMC9513137/ /pubmed/36176441 http://dx.doi.org/10.3389/fphar.2022.979951 Text en Copyright © 2022 Zhang, Li, Fang, Wei, Wang, Jin, Yang and Chen. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Zhang, Juzheng
Li, Yanping
Fang, Ronghao
Wei, Wei
Wang, Yong
Jin, Jiamin
Yang, Feng
Chen, Jian
Organometallic gold(I) and gold(III) complexes for lung cancer treatment
title Organometallic gold(I) and gold(III) complexes for lung cancer treatment
title_full Organometallic gold(I) and gold(III) complexes for lung cancer treatment
title_fullStr Organometallic gold(I) and gold(III) complexes for lung cancer treatment
title_full_unstemmed Organometallic gold(I) and gold(III) complexes for lung cancer treatment
title_short Organometallic gold(I) and gold(III) complexes for lung cancer treatment
title_sort organometallic gold(i) and gold(iii) complexes for lung cancer treatment
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9513137/
https://www.ncbi.nlm.nih.gov/pubmed/36176441
http://dx.doi.org/10.3389/fphar.2022.979951
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