Hyperuricemia contributes to glucose intolerance of hepatic inflammatory macrophages and impairs the insulin signaling pathway via IRS2-proteasome degradation

AIM: Numerous reports have demonstrated the key importance of macrophage-elicited metabolic inflammation in insulin resistance (IR). Our previous studies confirmed that hyperuricemia or high uric acid (HUA) treatment induced an IR state in several peripheral tissues to promote the development of typ...

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Detalles Bibliográficos
Autores principales: Zhao, Hairong, Lu, Jiaming, He, Furong, Wang, Mei, Yan, Yunbo, Chen, Binyang, Xie, De, Xu, Chenxi, Wang, Qiang, Liu, Weidong, Yu, Wei, Xi, Yuemei, Yu, Linqian, Yamamoto, Tetsuya, Koyama, Hidenori, Wang, Wei, Zhang, Chenggui, Cheng, Jidong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9513153/
https://www.ncbi.nlm.nih.gov/pubmed/36177037
http://dx.doi.org/10.3389/fimmu.2022.931087

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