Met/Val129 polymorphism of the full-length human prion protein dictates distinct pathways of amyloid formation

Methionine/valine polymorphism at position 129 of the human prion protein, huPrP, is tightly associated with the pathogenic phenotype, disease progress, and age of onset of neurodegenerative diseases such as Creutzfeldt–Jakob disease or Fatal Familial Insomnia. This raises the question of whether an...

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Detalles Bibliográficos
Autores principales: Pauly, Thomas, Bolakhrif, Najoua, Kaiser, Jesko, Nagel-Steger, Luitgard, Gremer, Lothar, Gohlke, Holger, Willbold, Dieter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Accelerated Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9513279/
https://www.ncbi.nlm.nih.gov/pubmed/36037966
http://dx.doi.org/10.1016/j.jbc.2022.102430

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