A previously uncharacterized O-glycopeptidase from Akkermansia muciniphila requires the Tn-antigen for cleavage of the peptide bond

Akkermansia muciniphila is key member of the human gut microbiota that impacts many features of host health. A major characteristic of this bacterium is its interaction with host mucin, which is abundant in the gut environment, and its ability to metabolize mucin as a nutrient source. The machinery...

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Detalles Bibliográficos
Autores principales: Medley, Brendon J., Leclaire, Leif, Thompson, Nicole, Mahoney, Keira E., Pluvinage, Benjamin, Parson, Matthew A.H., Burke, John E., Malaker, Stacy, Wakarchuk, Warren, Boraston, Alisdair B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9513282/
https://www.ncbi.nlm.nih.gov/pubmed/36049519
http://dx.doi.org/10.1016/j.jbc.2022.102439

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