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Dietary mannan oligosaccharides strengthens intestinal immune barrier function via multipath cooperation during Aeromonas Hydrophila infection in grass carp (Ctenopharyngodon Idella)
In recent years, mannose oligosaccharide (MOS) as a functional additive is widely used in aquaculture, to enhance fish immunity. An evaluation of the effect of dietary MOS supplementation on the immune barrier function and related signaling molecules mechanism of grass carp (Ctenopharyngodon idella)...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9513311/ https://www.ncbi.nlm.nih.gov/pubmed/36177013 http://dx.doi.org/10.3389/fimmu.2022.1010221 |
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author | Lu, Zhi-Yuan Feng, Lin Jiang, Wei-Dan Wu, Pei Liu, Yang Jiang, Jun Kuang, Sheng-Yao Tang, Ling Li, Shu-Wei Zhong, Cheng-Bo Zhou, Xiao-Qiu |
author_facet | Lu, Zhi-Yuan Feng, Lin Jiang, Wei-Dan Wu, Pei Liu, Yang Jiang, Jun Kuang, Sheng-Yao Tang, Ling Li, Shu-Wei Zhong, Cheng-Bo Zhou, Xiao-Qiu |
author_sort | Lu, Zhi-Yuan |
collection | PubMed |
description | In recent years, mannose oligosaccharide (MOS) as a functional additive is widely used in aquaculture, to enhance fish immunity. An evaluation of the effect of dietary MOS supplementation on the immune barrier function and related signaling molecules mechanism of grass carp (Ctenopharyngodon idella) was undertaken in the present study. Six diets with graded amounts of MOS supplementation (0, 200, 400, 600, 800, and 1000 mg/kg) were fed to 540 grass carp over 60 days. To examine the immune response and potential mechanisms of MOS supplementation on the intestine, a challenge test was conducted using injections of Aeromonas hydrophila for 14 days. Results of the study on the optimal supplementation with MOS were found as follows (1) MOS enhances immunity partly related to increasing antibacterial substances content and antimicrobial peptides expression; (2) MOS attenuates inflammatory response partly related to regulating the dynamic balance of intestinal inflammatory cytokines; (3) MOS regulates immune barrier function may partly be related to modulating TLRs/MyD88/NFκB and TOR/S6K1/4EBP signalling pathways. Finally, the current study concluded that MOS supplementation could improve fish intestinal immune barrier function under Aeromonas hydrophila infected conditions. |
format | Online Article Text |
id | pubmed-9513311 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-95133112022-09-28 Dietary mannan oligosaccharides strengthens intestinal immune barrier function via multipath cooperation during Aeromonas Hydrophila infection in grass carp (Ctenopharyngodon Idella) Lu, Zhi-Yuan Feng, Lin Jiang, Wei-Dan Wu, Pei Liu, Yang Jiang, Jun Kuang, Sheng-Yao Tang, Ling Li, Shu-Wei Zhong, Cheng-Bo Zhou, Xiao-Qiu Front Immunol Immunology In recent years, mannose oligosaccharide (MOS) as a functional additive is widely used in aquaculture, to enhance fish immunity. An evaluation of the effect of dietary MOS supplementation on the immune barrier function and related signaling molecules mechanism of grass carp (Ctenopharyngodon idella) was undertaken in the present study. Six diets with graded amounts of MOS supplementation (0, 200, 400, 600, 800, and 1000 mg/kg) were fed to 540 grass carp over 60 days. To examine the immune response and potential mechanisms of MOS supplementation on the intestine, a challenge test was conducted using injections of Aeromonas hydrophila for 14 days. Results of the study on the optimal supplementation with MOS were found as follows (1) MOS enhances immunity partly related to increasing antibacterial substances content and antimicrobial peptides expression; (2) MOS attenuates inflammatory response partly related to regulating the dynamic balance of intestinal inflammatory cytokines; (3) MOS regulates immune barrier function may partly be related to modulating TLRs/MyD88/NFκB and TOR/S6K1/4EBP signalling pathways. Finally, the current study concluded that MOS supplementation could improve fish intestinal immune barrier function under Aeromonas hydrophila infected conditions. Frontiers Media S.A. 2022-09-13 /pmc/articles/PMC9513311/ /pubmed/36177013 http://dx.doi.org/10.3389/fimmu.2022.1010221 Text en Copyright © 2022 Lu, Feng, Jiang, Wu, Liu, Jiang, Kuang, Tang, Li, Zhong and Zhou https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Lu, Zhi-Yuan Feng, Lin Jiang, Wei-Dan Wu, Pei Liu, Yang Jiang, Jun Kuang, Sheng-Yao Tang, Ling Li, Shu-Wei Zhong, Cheng-Bo Zhou, Xiao-Qiu Dietary mannan oligosaccharides strengthens intestinal immune barrier function via multipath cooperation during Aeromonas Hydrophila infection in grass carp (Ctenopharyngodon Idella) |
title | Dietary mannan oligosaccharides strengthens intestinal immune barrier function via multipath cooperation during Aeromonas Hydrophila infection in grass carp (Ctenopharyngodon Idella) |
title_full | Dietary mannan oligosaccharides strengthens intestinal immune barrier function via multipath cooperation during Aeromonas Hydrophila infection in grass carp (Ctenopharyngodon Idella) |
title_fullStr | Dietary mannan oligosaccharides strengthens intestinal immune barrier function via multipath cooperation during Aeromonas Hydrophila infection in grass carp (Ctenopharyngodon Idella) |
title_full_unstemmed | Dietary mannan oligosaccharides strengthens intestinal immune barrier function via multipath cooperation during Aeromonas Hydrophila infection in grass carp (Ctenopharyngodon Idella) |
title_short | Dietary mannan oligosaccharides strengthens intestinal immune barrier function via multipath cooperation during Aeromonas Hydrophila infection in grass carp (Ctenopharyngodon Idella) |
title_sort | dietary mannan oligosaccharides strengthens intestinal immune barrier function via multipath cooperation during aeromonas hydrophila infection in grass carp (ctenopharyngodon idella) |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9513311/ https://www.ncbi.nlm.nih.gov/pubmed/36177013 http://dx.doi.org/10.3389/fimmu.2022.1010221 |
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