Crystal structure of the α-ketoglutarate-dependent non-heme iron oxygenase CmnC in capreomycin biosynthesis and its engineering to catalyze hydroxylation of the substrate enantiomer

CmnC is an α-ketoglutarate (α-KG)-dependent non-heme iron oxygenase involved in the formation of the l-capreomycidine (l-Cap) moiety in capreomycin (CMN) biosynthesis. CmnC and its homologues, VioC in viomycin (VIO) biosynthesis and OrfP in streptothricin (STT) biosynthesis, catalyze hydroxylation o...

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Detalles Bibliográficos
Autores principales: Hsiao, Yu-Hsuan, Huang, Szu-Jo, Lin, En-Chi, Hsiao, Po-Yun, Toh, Shu-Ing, Chen, I-Hsuan, Xu, Zhengren, Lin, Yu-Pei, Liu, Hsueh-Ju, Chang, Chin-Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9513391/
https://www.ncbi.nlm.nih.gov/pubmed/36176888
http://dx.doi.org/10.3389/fchem.2022.1001311

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