N-terminal BET bromodomain inhibitors disrupt a BRD4-p65 interaction and reduce inducible nitric oxide synthase transcription in pancreatic β-cells

Chronic inflammation of pancreatic islets is a key driver of β-cell damage that can lead to autoreactivity and the eventual onset of autoimmune diabetes (T1D). In the islet, elevated levels of proinflammatory cytokines induce the transcription of the inducible nitric oxide synthase (iNOS) gene, NOS2...

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Detalles Bibliográficos
Autores principales: Nord, Joshua A., Wynia-Smith, Sarah L., Gehant, Alyssa L., Jones Lipinski, Rachel A., Naatz, Aaron, Rioja, Inmaculada, Prinjha, Rab K., Corbett, John A., Smith, Brian C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9513428/
https://www.ncbi.nlm.nih.gov/pubmed/36176467
http://dx.doi.org/10.3389/fendo.2022.923925

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